Amino-PEG5-alcohol - CAS 34188-11-9

Amino-PEG5-alcohol - CAS 34188-11-9 Catalog number: BADC-01117

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NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
Amino-PEG5-alcohol
CAS
34188-11-9
Catalog Number
BADC-01117
Molecular Formula
C10H23NO5
Molecular Weight
237.29
Purity
≥95%
Amino-PEG5-alcohol

Ordering Information

Catalog Number Size Price Quantity
BADC-01117 -- $-- Inquiry
Description
NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
NH2-PEG5-OH; 14-Amino-3,6,9,12-tetraoxatetradecan-1-ol
IUPAC Name
2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethanol
Canonical SMILES
C(COCCOCCOCCOCCO)N
InChI
InChI=1S/C10H23NO5/c11-1-3-13-5-7-15-9-10-16-8-6-14-4-2-12/h12H,1-11H2
InChIKey
DEOUHEFHTMMUCM-UHFFFAOYSA-N
Density
1.1±0.0 g/cm3
Solubility
Soluble in DMSO (10 mm)
Flash Point
163.2±0.0 °C
Index Of Refraction
1.460
LogP
-2.44
Vapor Pressure
0.0±0.0 mmHg at 25°C
Appearance
Pale Yellow or Colorless Oily Matter
Shipping
Room temperature, or blue ice upon request.
Storage
Store at 2-8°C
Boiling Point
346.3±0.0 °C at 760 mmHg
Form
Solid
Biological Activity
NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a noncleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2] . In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1] . ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2] .

Amino-PEG5-alcohol, a versatile reagent in bioconjugation and polymer chemistry, showcases diverse applications in biomedical research and biotechnology. Here are four key applications, each presented with a high degree of perplexity and burstiness:

Bioconjugation: By leveraging the unique properties of Amino-PEG5-alcohol, scientists intricately intertwine proteins, peptides, and various biomolecules, securing them to an array of surfaces or carriers. The incorporation of the PEG moiety not only enhances solubility and biocompatibility but also drives the advancement of targeted drug delivery systems and diagnostic tools to the forefront of innovation.

Surface Modification: Amino-PEG5-alcohol commands the spotlight in the art of surface modification, a critical technique applied to nanoparticles, medical implants, and biosensors. Through tailored adjustments to these surfaces, enhancing biocompatibility and minimizing nonspecific binding, the amino group facilitates covalent attachments to surface-active agents. This establishment of a hydrophilic barrier repels unwanted proteins and cells, optimizing the performance of medical devices and biosensors.

Polymer Synthesis: Within the intricate realm of polymer chemistry, Amino-PEG5-alcohol serves as a cornerstone for crafting specialized polymers with unique functionalities. The presence of amino and hydroxyl groups offers reactive hubs for subsequent chemical alterations and cross-linking reactions, paving the way for tailored polymers across a spectrum of applications, from hydrogels to drug delivery systems and tissue engineering scaffolds. This intricate polymerization process highlights the boundless versatility of Amino-PEG5-alcohol in the realm of polymer science, unlocking new horizons of material design.

Cell Culture Applications: Emerging as a pivotal tool within the domain of cell culture, Amino-PEG5-alcohol facilitates the engineering of surface functionalities that promote specific cellular adhesion and proliferation. Through the attachment of bioactive peptides or proteins onto PEGylated surfaces, researchers sculpt a controlled microenvironment conducive to cell growth, laying the groundwork for scientific breakthroughs in areas such as stem cell research and tissue engineering. This precision engineering of cellular behavior underscores the indispensable nature of Amino-PEG5-alcohol in orchestrating advancements at the forefront of scientific inquiry.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Amino-PEG5-alcohol
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