Aminooxy-PEG2-alcohol - CAS 185022-12-2

Aminooxy-PEG2-alcohol - CAS 185022-12-2 Catalog number: BADC-01012

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Aminooxy-PEG2-alcohol is a non-cleavable 2-unit PEG ADC linker that is used in the synthesis of antibody conjugated drugs (ADCs). Aminooxy-PEG2-alcohol is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules.

Category
ADCs Linker
Product Name
Aminooxy-PEG2-alcohol
CAS
185022-12-2
Catalog Number
BADC-01012
Molecular Formula
C4H11NO3
Molecular Weight
121.14
Aminooxy-PEG2-alcohol

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BADC-01012 -- $--
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Description
Aminooxy-PEG2-alcohol is a non-cleavable 2-unit PEG ADC linker that is used in the synthesis of antibody conjugated drugs (ADCs). Aminooxy-PEG2-alcohol is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules.
Synonyms
2-[2-(aminooxy)ethoxy]ethan-1-ol; O-[2-(2-Hydroxyethoxy)ethyl]hydroxylamine; Ethanol, 2-[2-(aminooxy)ethoxy]-
IUPAC Name
2-(2-aminooxyethoxy)ethanol
Canonical SMILES
C(COCCON)O
InChI
InChI=1S/C4H11NO3/c5-8-4-3-7-2-1-6/h6H,1-5H2
InChIKey
CMECGOAFIHUPBI-UHFFFAOYSA-N
Density
1.116±0.06 g/cm3 (Predicted)
Solubility
10 mm in DMSO
Appearance
Pale Yellow or Colorless Oily Matter
Purity
≥95%
Shelf Life
≥ 2 years
Shipping
Room temperature
Storage
Store at 2-8°C
Boiling Point
265.9±20.0°C (Predicted)
Form
Solid

Aminooxy-PEG2-alcohol, a versatile compound with diverse applications in biomedical and biotechnological research, presents numerous opportunities for advancement. Here are four key applications crafted with high perplexity and burstiness:

Bioconjugation: Functioning as a bioconjugation reagent, Aminooxy-PEG2-alcohol enables the precise attachment of various biomolecules, such as proteins, peptides, or antibodies, to surfaces or other molecules. Its unique reactivity with aldehyde or ketone groups allows for site-specific conjugation, a critical element in the development of diagnostic assays, therapeutic agents, and targeted drug delivery systems. The intricate capabilities of Aminooxy-PEG2-alcohol in facilitating such precise conjugations underscore its significance in the domains of biomedical research and biotechnology.

Protein Labeling: Within the realm of proteomics, Aminooxy-PEG2-alcohol assumes a pivotal role in selectively labeling proteins to track and analyze protein interactions, distribution, and function within biological systems. Through the modification of proteins with this compound, researchers can plunge into the dynamic realm of protein dynamics and interactions, shedding light on the complexities of cellular processes. This application emphasizes the importance of Aminooxy-PEG2-alcohol in unraveling the intricate tapestry of protein-related phenomena within biological systems.

Glycobiology: Aminooxy-PEG2-alcohol finds its niche in the exploration of glycoproteins and glycans, enabling the labeling and identification of crucial carbohydrate moieties. By engaging with oxidized sugars, this reagent empowers scientists to delve into protein glycosylation patterns and their implications in diverse biological functions and diseases. The realm of glycobiology, enriched by the capabilities of Aminooxy-PEG2-alcohol, holds the key to unraveling the enigmas surrounding immune responses, cell signaling, and disease biomarkers, showcasing the compound's significance in unlocking the mysteries of intricate biological systems.

Drug Delivery Development: In the landscape of drug delivery research, Aminooxy-PEG2-alcohol emerges as a pivotal component in attaching therapeutic agents to delivery vehicles like liposomes or nanoparticles through oxime bond formation. This strategic approach ensures the precise release of drugs at the designated target site, minimizing off-target effects and amplifying therapeutic efficacy. The precision and control offered by Aminooxy-PEG2-alcohol in drug delivery systems underscore its role in the advancement of sophisticated and safer drug delivery mechanisms.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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