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Aminooxy-PEG3-azide is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Aminooxy-C2-PEG3-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00918 | -- | $-- |
Aminooxy-PEG3-azide, a versatile chemical linker widely employed in bioconjugation and crosslinking, finds diverse applications in the following areas represented with heightened perplexity and burstiness:
Bioconjugation: Leveraging Aminooxy-PEG3-azide for bioconjugation purposes fosters the coupling of proteins, peptides, and other biomolecules with exceptional precision. This compound facilitates site-specific conjugation via oxime ligation, ensuring robust and effective attachment mechanisms. Such conjugations play a pivotal role in crafting targeted drug delivery systems and diagnostic tools, revolutionizing the realms of biomedicine.
Click Chemistry: Positioned as a cornerstone reagent in click chemistry, Aminooxy-PEG3-azide plays a pivotal role in catalyzing azide-alkyne cycloaddition reactions, particularly in the presence of copper. This dynamic enables the swift and selective formation of triazoles, expediting the synthesis of intricate molecules. Widely embraced in medicinal chemistry, material science, and nanotechnology, this technology drives innovation and complexity in various scientific domains.
Surface Modification: Unveiling its prowess in surface modification, Aminooxy-PEG3-azide emerges as a transformative tool for functionalizing diverse substrates like glass, nanoparticles, and polymers. By immobilizing biomolecules on these surfaces, researchers cultivate bioactive interfaces tailored for biosensors, bioassays, and tissue engineering endeavors. This breakthrough underscores significant progress in diagnostic platforms and biomedical devices, propelling the frontier of biotechnological advancements.
Drug Delivery: Within the realm of drug delivery, Aminooxy-PEG3-azide assumes a critical role in crafting drug conjugates and delivery vehicles engineered for precision and efficacy. The incorporation of the PEG linker enhances drug solubility and stability, while the azide group provides a platform for further functionalization. This strategic approach fortifies targeted drug delivery mechanisms, amplifying the therapeutic potential and efficacy of pharmaceutical agents.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
