BS2G Crosslinker (disodium) - CAS 881415-72-1

BS2G Crosslinker (disodium) - CAS 881415-72-1 Catalog number: BADC-01183

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BS2G Crosslinker (disodium) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
BS2G Crosslinker (disodium)
CAS
881415-72-1
Catalog Number
BADC-01183
Molecular Formula
C13H12N2Na2O14S2
Molecular Weight
530.35

Ordering Information

Catalog Number Size Price Quantity
BADC-01183 -- $--
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Description
BS2G Crosslinker (disodium) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
Disodium;1-[5-(2,5-dioxopyrrolidin-4-id-1-yl)oxy-5-oxopentanoyl]oxy-2,5-dioxopyrrolidine-3-sulfonate;sulfur trioxide
IUPAC Name
disodium; 1-[5-(2,5-dioxopyrrolidin-4-id-1-yl)oxy-5-oxopentanoyl]oxy-2,5-dioxopyrrolidine-3-sulfonate; sulfur trioxide
Canonical SMILES
C1[CH-]C(=O)N(C1=O)OC(=O)CCCC(=O)ON2C(=O)CC(C2=O)S(=O)(=O)[O-].O=S(=O)=O.[Na+].[Na+]
InChI
InChI=1S/C13H13N2O11S.2Na.O3S/c16-8-4-5-9(17)14(8)25-11(19)2-1-3-12(20)26-15-10(18)6-7(13(15)21)27(22,23)24;;;1-4(2)3/h4,7H,1-3,5-6H2,(H,22,23,24);;;/q-1;2*+1;/p-1
InChIKey
NQKDBYNZYPOUIN-UHFFFAOYSA-M
Solubility
10 mm in DMSO
PSA
252.86000
Appearance
Solid
Purity
>98.0%
Shelf Life
-20°C 3 years powder; -80°C 2 years in solvent
Shipping
Room temperature
Storage
-20°C
Form
Solid

BS2G Crosslinker (disodium), a versatile reagent utilized in biochemical and structural biology research, offers a myriad of applications with high perplexity and burstiness.

Protein-Protein Interaction Studies: Widely employed in investigating protein-protein interactions, BS2G Crosslinker (disodium) facilitates the covalent linking of interacting proteins to stabilize complexes. Through techniques like mass spectrometry and gel electrophoresis, researchers can analyze and map interaction sites, unraveling intricate protein networks.

Antibody Conjugation: In immunological assays, BS2G Crosslinker (disodium) serves to conjugate antibodies to various labels, such as enzymes, fluorophores, or nanoparticles. This conjugation enables the detection and quantification of specific antigens in techniques like ELISA and flow cytometry, enhancing the sensitivity and specificity of diagnostic tests significantly.

Drug Delivery Systems: Pioneering the development of targeted drug delivery systems, BS2G Crosslinker (disodium) aids in crosslinking therapeutic agents with targeting ligands to create precise conjugates that specifically bind to diseased cells. By minimizing side effects and enhancing treatment efficacy, this targeted approach revolutionizes drug delivery mechanisms.

Enzyme Immobilization: In the realm of biotechnology, BS2G Crosslinker (disodium) finds application in immobilizing enzymes onto solid supports for heightened stability and reusability. Immobilized enzymes play pivotal roles in various industrial processes, spanning biosensors, biofuel production, and pharmaceutical manufacturing, enabling continuous biocatalysis and driving down process costs effectively.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: BS2G Crosslinker (disodium)
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