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Anetumab-MMAE is an antibody-drug conjugate consisting of an anti-MSLN monoclonal antibody and monomethyl auristatin E (MMAE). MMAE is an antimitotic agent that inhibits tubulin polymerization.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01598 | -- | $-- |
Anetumab-MMAE, an antibody-drug conjugate (ADC) engineered to selectively target and eradicate cancer cells expressing mesothelin, offers a myriad of applications. Here are four key applications of Anetumab-MMAE:
Cancer Treatment: Anetumab-MMAE emerges as a formidable weapon against cancers characterized by elevated mesothelin expression, including mesothelioma, ovarian cancer, and pancreatic cancer. This potent agent delivers a precise blow to mesothelin, facilitating the direct dispatch of a cytotoxic payload to malignant cells, leading to their annihilation while minimizing collateral damage to healthy tissues. This focused approach not only heightens therapeutic efficacy but also mitigates systemic side effects, heralding a transformative era in the realm of targeted cancer therapies.
Research Tool in Oncology: Within the realm of cancer research, Anetumab-MMAE assumes a pivotal role as a tool that empowers scientists to unravel the impact of targeted therapies on mesothelin-presenting tumors. Serving as a discerning lens, this ADC enables researchers to dissect tumor responses, resistance mechanisms, and potential synergistic therapies in preclinical models. Such investigations propel the advancement of more potent treatment strategies and personalized medicinal approaches, reshaping the landscape of oncological research.
Companion Diagnostics Development: The advent of Anetumab-MMAE has sparked the evolution of companion diagnostics tailored to identify patients most likely to benefit from mesothelin-targeted therapies. Diagnostic assays have been refined to detect mesothelin expression levels within tumor tissues, guiding treatment decisions with pinpoint precision. This precision-crafted approach ensures that treatments align with the molecular profile of the patient's cancer, pioneering a new frontier in personalized cancer care.
Combination Therapy Studies: In the quest for optimal treatment outcomes, Anetumab-MMAE is undergoing rigorous scrutiny in combination with a spectrum of therapeutic agents. Investigations delve into its interplay with immunotherapies, chemotherapy, and radiation, seeking synergies that amplify patient responses.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
