APN-PEG36-tetrazine

APN-PEG36-tetrazine Catalog number: BADC-01871

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APN-PEG36-tetrazine is a cleavable 36 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
APN-PEG36-tetrazine
Catalog Number
BADC-01871
Molecular Formula
C94H161N7O38
Molecular Weight
1997.30

Ordering Information

Catalog Number Size Price Quantity
BADC-01871 -- $--
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Description
APN-PEG36-tetrazine is a cleavable 36 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
IUPAC Name
4-(2-cyanoethynyl)-N-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[3-oxo-3-[[4-(1,2,4,5-tetrazin-3-yl)phenyl]methylamino]propoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]benzamide
Canonical SMILES
C1=CC(=CC=C1CNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)C2=CC=C(C=C2)C#CC#N)C3=NN=CN=N3
InChI
InChI=1S/C94H161N7O38/c95-12-1-2-88-3-9-91(10-4-88)94(103)96-13-15-105-17-19-107-21-23-109-25-27-111-29-31-113-33-35-115-37-39-117-41-43-119-45-47-121-49-51-123-53-55-125-57-59-127-61-63-129-65-67-131-69-71-133-73-75-135-77-79-137-81-83-139-85-84-138-82-80-136-78-76-134-74-72-132-70-68-130-66-64-128-62-60-126-58-56-124-54-52-122-50-48-120-46-44-118-42-40-116-38-36-114-34-32-112-30-28-110-26-24-108-22-20-106-18-16-104-14-11-92(102)97-86-89-5-7-90(8-6-89)93-100-98-87-99-101-93/h3-10,87H,11,13-86H2,(H,96,103)(H,97,102)
InChIKey
DNPOMSGFFGGZFE-UHFFFAOYSA-N
Appearance
Pink to Red Solid

APN-PEG36-tetrazine, a versatile bioconjugation reagent with wide-ranging applications in science and medicine. Here are four key applications presented with high perplexity and burstiness:

Bioorthogonal Chemistry: Leveraging the unique properties of APN-PEG36-tetrazine, researchers engage in bioorthogonal chemical reactions that enable precise and efficient conjugation within biological systems, all while preserving native biochemical processes. This capability empowers the selective labeling of biomolecules within live cells and organisms with unparalleled specificity. In the realm of imaging studies and dynamic biological process tracking, this reagent plays a pivotal role.

Targeted Drug Delivery: At the forefront of precision medicine, APN-PEG36-tetrazine plays a pivotal role in targeted drug delivery by facilitating the attachment of therapeutic agents to specific cellular targets via click chemistry. This novel approach enhances the accuracy of drug delivery by conjugating drugs with targeting molecules like antibodies or peptides. The result is a targeted delivery system that ensures therapeutic agents reach their intended destination with minimal off-target effects, offering new possibilities for more effective and safer treatments, especially in complex diseases like cancer.

Nanoparticle Functionalization: Delving into the realm of nanotechnology, APN-PEG36-tetrazine serves as a key player in modifying the surface of nanoparticles, facilitating the attachment of diverse functional groups for diagnostic and therapeutic purposes. This functionalization enhances the biocompatibility, targeting precision, and stability of nanoparticles within biological environments. The resultant functionalized nanoparticles find applications in drug delivery, imaging, and biosensing, heralding a new era in nanomedicine with enhanced capabilities for personalized healthcare.

Protein and Peptide Labeling: Driving advancements in proteomics and biochemistry, APN-PEG36-tetrazine finds its niche in the precise labeling of proteins and peptides, enabling detailed analysis of protein interactions, localization, and function. Through site-specific conjugation, this reagent aids in the creation of protein conjugates that maintain their biological activity, facilitating deep dives into protein dynamics and interactions within complex biological systems. This application is indispensable for unraveling the intricacies of cellular processes and holds immense potential for advancing our understanding of fundamental biological mechanisms.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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