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Azido-PEG3-NHS ester is a non-cleavable 3-unit PEG linker that can be used to synthesize antibody-conjugated drugs (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00407 | -- | $-- |
Azido-PEG3-NHS ester, a versatile reagent harnessed in bioconjugation and molecular biology, finds applications across diverse domains. Here are four key applications of Azido-PEG3-NHS ester articulated with a distinctive blend of perplexity and burstiness:
Click Chemistry: Integral to click chemistry, Azido-PEG3-NHS ester plays a pivotal role in bioconjugation. This reagent introduces an azide group to biomolecules, facilitating their efficient linkage to alkyne-containing molecules through a copper-catalyzed azide-alkyne cycloaddition reaction. This method is instrumental in crafting intricate biomolecular assemblies and tagging proteins or peptides with an array of probes.
Protein Labeling: Azido-PEG3-NHS ester emerges as a key player in labeling proteins with fluorescent dyes or other bioactive molecules. By engaging with primary amines on proteins, this reagent covalently affixes an azide group, which can subsequently be linked to a myriad of detection or functional tags. This application is paramount for investigating protein dynamics, interactions, and localization within biological systems.
Drug Delivery: Positioned at the forefront of targeted drug delivery systems, Azido-PEG3-NHS ester showcases its capabilities. The PEG linker confers solubility and diminishes immunogenicity, while the azide group facilitates the attachment of therapeutic agents or targeting moieties. This precision enables the targeted delivery of drugs to specific cells or tissues, augmenting therapeutic effectiveness while minimizing side effects.
Surface Modification: Aiding in the modification of surfaces of nanoparticles, biosensors, and other biomaterials, Azido-PEG3-NHS ester stands out for its versatility. By introducing azide groups onto surfaces, it enables the binding of various biofunctional molecules through click chemistry. This application is indispensable in creating biointerfaces with enhanced biocompatibility, specificity, and functionalization for diagnostic and therapeutic endeavors.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
