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Azido-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-maleimide is also a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01013 | -- | $-- |
Azido-PEG3-maleimide, a versatile heterobifunctional crosslinker with widespread use in biochemical and biotechnological research, serves as the cornerstone for a myriad of applications. Here are four key applications of Azido-PEG3-maleimide, presented with high perplexity and burstiness:
Bioconjugation: Positioned at the forefront of bioconjugation techniques, Azido-PEG3-maleimide plays a crucial role in connecting proteins, peptides, or other biomolecules through their thiol groups. The azido group’s remarkable versatility enables seamless integration into click chemistry reactions, providing a reliable pathway for site-specific conjugation. This remarkable capability facilitates the intricate assembly of bioconjugates tailored for a diverse array of applications, spanning from cutting-edge drug delivery to state-of-the-art diagnostic imaging.
Drug Delivery Systems: Harnessing the transformative potential of Azido-PEG3-maleimide, researchers can engineer sophisticated drug delivery systems by modifying therapeutic agents or carrier molecules. This compound empowers precise attachment of drugs to carriers, like nanoparticles or liposomes, via thiol groups, enabling targeted delivery. The resulting constructs exhibit augmented pharmacokinetics and biodistribution, significantly enhancing the therapeutic efficacy of a wide array of drugs.
Surface Modification: Azido-PEG3-maleimide emerges as an indispensable asset for enhancing the biocompatibility and functionality of biomaterials or nanoparticles through surface modification. By anchoring this crosslinker to surfaces, researchers can introduce azide groups capable of engaging in click chemistry reactions for further functionalization. This application serves as a linchpin in the advancement of cutting-edge biosensors, medical implants, and other biomedical devices, pushing the boundaries of biotechnological innovation.
Protein Labeling: Within the intricate realm of protein biology, Azido-PEG3-maleimide finds profound utility in specific protein labeling endeavors aimed at unraveling protein-protein interactions or intracellular localization. The maleimide group’s interaction with cysteine residues on proteins, coupled with the azido group’s ability to facilitate subsequent tagging with fluorescent probes via click chemistry, forms the foundation for a myriad of analytical and imaging applications in cell biology and biochemistry. This technique enables precise visualization and exploration of complex molecular processes, opening new avenues for research and discovery.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
