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Azido-PEG4-PFP ester is a versatile chemical compound widely used in the biomedicine field. This ester derivative is utilized for the modification and functionalization of biomolecules, such as peptides and proteins. Its azido group allows for further conjugation or attachment to various drugs, biomaterials, or surfaces. This enables targeted drug delivery, protein labeling, and immunoassays for disease diagnostics and therapeutics.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00404 | -- | $-- |
Azido-PEG4-PFP ester, a versatile reagent with vast applications in bioconjugation, drug delivery, and molecular imaging. Here are four key applications presented with high perplexity and burstiness.
Bioconjugation: Azido-PEG4-PFP ester plays a pivotal role in the conjugation of biomolecules, such as proteins and peptides, to fabricate multifunctional probes. Leveraging the reactive azido group, which can undergo bioorthogonal click chemistry reactions with alkyne or cyclooctyne groups, enables precise labeling of biomolecules. This application is essential for delving into protein-protein interactions, tracking intricate cellular processes, and crafting cutting-edge diagnostic tools.
Drug Delivery: At the forefront of drug delivery innovation, Azido-PEG4-PFP ester is harnessed for designing targeted drug delivery systems by tethering drugs to specific targeting moieties. The PEG spacer enhances drug solubility and stability, while the azido group permits site-specific linkage. This breakthrough allows for the creation of precision-targeted therapeutics capable of delivering drugs directly to disease sites, thus elevating efficacy while minimizing unwanted side effects.
Molecular Imaging: Unveiling the potential of Azido-PEG4-PFP ester in molecular imaging, where it serves to label imaging agents with targeting molecules. The PFP ester interacts with amino groups on targeting proteins, while the azido group enables subsequent bioorthogonal labeling with fluorescent dyes or radioactive isotopes. This cutting-edge approach facilitates real-time visualization of biological processes in vivo, thereby facilitating disease diagnosis and progression monitoring.
Nanotechnology: In the realm of nanotechnology, Azido-PEG4-PFP ester emerges as a cornerstone for functionalizing nanoparticles with bioactive molecules. Interacting with surface amino groups on nanoparticles, the PFP ester sets the stage for further click chemistry modifications facilitated by the azido group. This breakthrough is instrumental in engineering nanomaterials tailored for targeted drug delivery, biosensing applications, and therapeutic interventions.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
