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Azido-PEG9-acid is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00984 | -- | $-- |
Azido-PEG9-acid, a versatile derivative of polyethylene glycol featuring an azide group, serves as a potent tool in bioconjugation and material science. Here are four key applications of Azido-PEG9-acid presented with high perplexity and burstiness:
Bioconjugation: The strategic utilization of Azido-PEG9-acid in bioconjugation methodologies, employing click chemistry reactions, enables the conjugation of biomolecules. This process facilitates the attachment of a myriad of functional moieties, such as fluorescent labels or therapeutic agents, to proteins, peptides, or nucleic acids. This pivotal application plays a paramount role in the development of exquisitely precise targeted drug delivery systems and cutting-edge diagnostic tools.
Surface Modification: Azido-PEG9-acid offers unparalleled capabilities in modifying the surface properties of a diverse array of materials ranging from nanoparticles to polymers and biomedical devices. By tethering PEG chains, these surfaces undergo a transformation towards enhanced hydrophilicity and reduced non-specific binding, ultimately enhancing biocompatibility and mitigating fouling. This feature proves especially advantageous in propelling forward the frontier of innovative medical implants and state-of-the-art biosensors.
Drug Delivery: Leveraging Azido-PEG9-acid in the creation of PEGylated drug carriers elevates the pharmacokinetic properties of therapeutic molecules to unprecedented heights. PEGylation plays a pivotal role in extending the half-life of drugs in the bloodstream, thereby diminishing renal clearance and enhancing stability.
Crosslinking and Hydrogels: Azido-PEG9-acid plays an essential role in the formulation of cutting-edge hydrogels and other crosslinked networks through bio-orthogonal click reactions. These hydrogels find extensive applications in diverse fields such as tissue engineering, wound healing, and controlled drug release systems. The presence of the azide group enables precise and controlled crosslinking, facilitating the design of materials with customized mechanical and chemical properties.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
