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Biotin-PEG4-Dde-TAMRA-PEG3-Azide is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01098 | -- | $-- | Inquiry |
Biotin-PEG4-Dde-TAMRA-PEG3-Azide is a multifunctional chemical probe used extensively in bioconjugation and imaging studies. Here are some key applications of Biotin-PEG4-Dde-TAMRA-PEG3-Azide:
Protein Labeling and Affinity Purification: This reagent can be used for the biotinylation and subsequent purification of proteins. The biotin moiety enables strong binding to streptavidin- or avidin-coated surfaces, facilitating the isolation of target proteins. Meanwhile, the Dde (1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)ethyl) protection group provides a reversible option for downstream applications.
Fluorescence Microscopy: The TAMRA (Tetramethylrhodamine) fluorophore in Biotin-PEG4-Dde-TAMRA-PEG3-Azide allows for high-resolution imaging in fluorescence microscopy. Researchers use this compound to visualize cellular components in live or fixed cells. Its bright red fluorescence is particularly useful for multi-color imaging experiments.
Click Chemistry Applications: The azide group in this molecule is reactive in click chemistry, facilitating the attachment of various alkyne-modified probes or molecules. This makes it a versatile tool for introducing functional groups into biomolecules under milder conditions. Researchers can track biological processes or modify biomolecules with high precision and efficiency.
Surface Functionalization: Biotin-PEG4-Dde-TAMRA-PEG3-Azide can be employed to functionalize surfaces for biosensor development. The biotin and azide functionalities allow for versatile conjugation to various sensor substrates, improving the capture and detection of analytes. This is particularly advantageous in the creation of highly sensitive and specific diagnostic tools.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
