Biotin-PEG4-Dde-TAMRA-PEG3-Azide - CAS 2353409-56-8

Biotin-PEG4-Dde-TAMRA-PEG3-Azide - CAS 2353409-56-8 Catalog number: BADC-01098

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Biotin-PEG4-Dde-TAMRA-PEG3-Azide is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
Biotin-PEG4-Dde-TAMRA-PEG3-Azide
CAS
2353409-56-8
Catalog Number
BADC-01098
Molecular Formula
C69H96N12O17S
Molecular Weight
1397.64
Biotin-PEG4-Dde-TAMRA-PEG3-Azide

Ordering Information

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BADC-01098 -- $--
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Description
Biotin-PEG4-Dde-TAMRA-PEG3-Azide is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
Dde TAMRA Biotin Azide
IUPAC Name
5-[[3-[[3-[3-[[3-[2-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]-1-(2-hydroxy-4,4-dimethyl-6-oxocyclohexen-1-yl)propylidene]amino]propylamino]-3-oxopropyl]-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]amino]-3-oxopropyl]carbamoyl]-2-[3-(dimethylamino)-6-iminoxanthen-9-yl]benzoic acid
Canonical SMILES
CC1(CC(=C(C(=O)C1)C(=NCCCNC(=O)CCN(CCOCCOCCOCCN=[N+]=[N-])C(=O)CCNC(=O)C2=CC(=C(C=C2)C3=C4C=CC(=N)C=C4OC5=C3C=CC(=C5)N(C)C)C(=O)O)CCOCCOCCOCCOCCNC(=O)CCCCC6C7C(CS6)NC(=O)N7)O)C
InChI
InChI=1S/C69H96N12O17S/c1-69(2)43-55(82)64(56(83)44-69)53(18-26-91-30-34-95-38-39-97-35-31-92-27-22-74-60(84)9-6-5-8-59-65-54(45-99-59)77-68(90)78-65)72-19-7-20-73-61(85)17-24-81(25-29-94-33-37-96-36-32-93-28-23-76-79-71)62(86)16-21-75-66(87)46-10-13-49(52(40-46)67(88)89)63-50-14-11-47(70)41-57(50)98-58-42-48(80(3)4)12-15-51(58)63/h10-15,40-42,54,59,65,70,82H,5-9,16-39,43-45H2,1-4H3,(H,73,85)(H,74,84)(H,75,87)(H,88,89)(H2,77,78,90)/t54-,59-,65-/m0/s1
InChIKey
BZMNWSIWUFJKEL-RKILTYLGSA-N
Solubility
10 mm in DMSO
Appearance
Solid
Purity
>98.0%
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
Room temperature
Storage
Store at -20 °C, keep in dry and avoid sunlight.
Form
Solid

Biotin-PEG4-Dde-TAMRA-PEG3-Azide is a multifunctional chemical probe used extensively in bioconjugation and imaging studies. Here are some key applications of Biotin-PEG4-Dde-TAMRA-PEG3-Azide:

Protein Labeling and Affinity Purification: This reagent can be used for the biotinylation and subsequent purification of proteins. The biotin moiety enables strong binding to streptavidin- or avidin-coated surfaces, facilitating the isolation of target proteins. Meanwhile, the Dde (1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)ethyl) protection group provides a reversible option for downstream applications.

Fluorescence Microscopy: The TAMRA (Tetramethylrhodamine) fluorophore in Biotin-PEG4-Dde-TAMRA-PEG3-Azide allows for high-resolution imaging in fluorescence microscopy. Researchers use this compound to visualize cellular components in live or fixed cells. Its bright red fluorescence is particularly useful for multi-color imaging experiments.

Click Chemistry Applications: The azide group in this molecule is reactive in click chemistry, facilitating the attachment of various alkyne-modified probes or molecules. This makes it a versatile tool for introducing functional groups into biomolecules under milder conditions. Researchers can track biological processes or modify biomolecules with high precision and efficiency.

Surface Functionalization: Biotin-PEG4-Dde-TAMRA-PEG3-Azide can be employed to functionalize surfaces for biosensor development. The biotin and azide functionalities allow for versatile conjugation to various sensor substrates, improving the capture and detection of analytes. This is particularly advantageous in the creation of highly sensitive and specific diagnostic tools.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Biotin-PEG4-Dde-TAMRA-PEG3-Azide
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