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Bis(NHS)PEG5 is a non-cleavable 5-unit PEG linker that can be used to synthesize antibody-conjugated drugs (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00378 | -- | $-- |
Bis(NHS)PEG5, a versatile bifunctional polyethylene glycol (PEG) crosslinker, finds wide-ranging applications in bioconjugation and chemical biology. Here are four key applications of Bis(NHS)PEG5:
Protein-Protein Conjugation: This intricate process involves utilizing Bis(NHS)PEG5 to facilitate the conjugation of two proteins, forming stable amide bonds between their amino groups. Particularly crucial in creating antibody-drug conjugates for targeted cancer therapies, this crosslinker’s PEG spacer enhances solubility and reduces steric hindrance, optimizing the bioactivity of the resulting complex.
Surface Functionalization: Researchers leverage the power of Bis(NHS)PEG5 to modify surfaces of nanoparticles, biomaterials, and biosensors. By attaching Bis(NHS)PEG5, specific functional groups are introduced that enable the binding of molecules like antibodies or enzymes on diverse surfaces. This precision is pivotal in developing diagnostic devices and bioanalytical tools, ensuring high specificity and sensitivity in molecular interactions.
Drug Delivery Systems: Bis(NHS)PEG5 plays a pivotal role in creating polymer-based drug delivery systems with controlled release capabilities. Through PEGylation of drug carriers, such as liposomes or nanoparticles, using Bis(NHS)PEG5, stability and circulation time in the bloodstream are enhanced. This strategic approach enables more efficient drug targeting, reduces immunogenicity, and ultimately yields superior therapeutic outcomes for patients.
Tissue Engineering: In the domain of tissue engineering, Bis(NHS)PEG5 serves as a vital tool for crosslinking hydrogels and scaffolds, enhancing their mechanical strength and biocompatibility. By skillfully linking natural or synthetic polymers using Bis(NHS)PEG5, researchers create three-dimensional structures closely mimicking the extracellular matrix. This advancement supports crucial processes like cell attachment, proliferation, and differentiation, propelling tissue-engineered constructs forward in regenerative medicine.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
