Mal-PEG2-PFP - CAS 1807512-47-5

Mal-PEG2-PFP - CAS 1807512-47-5 Catalog number: BADC-00452

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Mal-PEG2-PFP is a PEG linker containing maleimide and PFP moieties. Maleimide is thiol-reactive and reacts between pH 6.5 and 7.5 to form thiol ester bonds. PFP moiety is amine-reactive and is less susceptible to undergoing hydrolysis. The hydrophilic PEG linker increases the water solubility of a compound in aqueous media.

Category
ADCs Linker
Product Name
Mal-PEG2-PFP
CAS
1807512-47-5
Catalog Number
BADC-00452
Molecular Formula
C17H14F5NO6
Molecular Weight
423.29
Purity
≥98%
Mal-PEG2-PFP

Ordering Information

Catalog Number Size Price Quantity
BADC-00452 -- $-- Inquiry
Description
Mal-PEG2-PFP is a PEG linker containing maleimide and PFP moieties. Maleimide is thiol-reactive and reacts between pH 6.5 and 7.5 to form thiol ester bonds. PFP moiety is amine-reactive and is less susceptible to undergoing hydrolysis. The hydrophilic PEG linker increases the water solubility of a compound in aqueous media.
Synonyms
Mal-PEG2-PFP ester; Perfluorophenyl 3-(2-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)ethoxy)propanoate; Perfluorophenyl 3-(2-(2-(2,5-dioxo-2H-pyrrol-1(5H)-yl)ethoxy)ethoxy)propanoate; Propanoic acid, 3-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-, 2,3,4,5,6-pentafluorophenyl ester
IUPAC Name
(2,3,4,5,6-pentafluorophenyl) 3-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]propanoate
Canonical SMILES
C1=CC(=O)N(C1=O)CCOCCOCCC(=O)Oc2c(c(c(c(c2F)F)F)F)F
InChI
InChI=1S/C17H14F5NO6/c18-12-13(19)15(21)17(16(22)14(12)20)29-11(26)3-5-27-7-8-28-6-4-23-9(24)1-2-10(23)25/h1-2H,3-8H2
InChIKey
YMKYKJKJMZSGEN-UHFFFAOYSA-N
Density
1.5±0.1 g/cm3
Solubility
Soluble in DCM, DMF, DMSO
Appearance
Soild powder
Shipping
Room temperature
Storage
Store at 2-8°C
Boiling Point
493.1±45.0°C at 760 mmHg
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: IgG1-VcMMAE | Mal-PEG2-PFP
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