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Mal-PEG2-NHS ester is a non-cleavable ADC linker containing the Maleimide group, 2-unit PEG, and NHS ester.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00453 | 100 mg | $629 | Inquiry |
Mal-PEG2-NHS, a chemical reagent essential for bioconjugation processes, plays a pivotal role in linking biomolecules for diverse applications.
Protein Conjugation: Widely utilized in biomedical research, Mal-PEG2-NHS acts as a versatile tool for binding proteins to a myriad of molecules, including dyes, drugs, or other proteins. Its NHS ester reacts with primary amines, enabling the creation of labeled proteins crucial for various imaging techniques or therapeutic interventions. The maleimide group provides selective linkage capabilities, preserving the protein's native functionality while facilitating intricate molecular connections.
Drug Delivery Systems: Leveraging the adaptable nature of Mal-PEG2-NHS, researchers delve into the realm of targeted drug delivery systems. By conjugating therapeutic agents or targeting ligands to carrier molecules, the specificity of drug delivery is heightened, minimizing off-target effects. This sophisticated methodology not only enhances drug efficacy but also ensures safer formulations.
Antibody-Drug Conjugates (ADCs): At the forefront of oncology research, Mal-PEG2-NHS plays a pivotal role in the synthesis of ADCs, where it orchestrates the coupling of cytotoxic drugs to monoclonal antibodies. This precision in conjugation ensures the direct delivery of therapeutic agents to cancer cells, sparing healthy tissue from damage.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
