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Mal-PEG6-NHS ester is a non-cleavable ADC linker containing the Maleimide group, 6-unit PEG, and NHS ester.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00499 | -- | $-- | Inquiry |
Mal-PEG6-NHS ester is a multifunctional reagent widely used in the fields of drug delivery, diagnostics, and biomolecule labeling. The compound features a maleimide (Mal) group, which enables selective conjugation with thiol-containing molecules, such as peptides, proteins, and antibodies. The PEG6 spacer improves the solubility and stability of the conjugate in aqueous solutions, which is crucial for enhancing the pharmacokinetics of drug conjugates. The NHS ester group allows efficient coupling to amine-containing molecules, making Mal-PEG6-NHS ester a valuable tool in the development of antibody-drug conjugates (ADCs), peptide-based therapies, and molecular diagnostics.
One of the most prominent applications of Mal-PEG6-NHS ester is in the creation of antibody-drug conjugates (ADCs) for targeted cancer therapy. By attaching cytotoxic drugs or small molecule payloads to monoclonal antibodies through the NHS ester, Mal-PEG6-NHS ester enables the targeted delivery of potent therapeutic agents directly to tumor cells. The maleimide group reacts with thiol-containing antibodies or proteins, while the PEG6 spacer ensures increased solubility, reducing immunogenicity and improving circulation time in the bloodstream. This targeted approach minimizes off-target toxicity and enhances the therapeutic efficacy of chemotherapy drugs.
Mal-PEG6-NHS ester is also highly effective in the development of peptide-drug conjugates (PDCs), which are used for the delivery of small molecules or bioactive agents to specific targets. The PEG6 spacer provides excellent solubility and stability, ensuring that the conjugates remain biologically active over extended periods. The NHS ester facilitates the coupling of drugs to peptides via amine groups, which allows for precise control over the release and delivery of the therapeutic agents. This application is particularly beneficial in precision medicine, where customized drug delivery systems are needed for effective treatment with minimal side effects.
In addition to its role in drug delivery, Mal-PEG6-NHS ester is widely utilized in molecular imaging and diagnostic applications. By conjugating antibodies or peptides to imaging agents, this compound enables the precise targeting of disease biomarkers for enhanced imaging accuracy. The PEG6 spacer helps improve the pharmacokinetic properties of the conjugates, ensuring better tissue penetration and prolonged circulation. The NHS ester reacts efficiently with amine groups, allowing for the creation of stable conjugates that are ideal for applications such as positron emission tomography (PET), magnetic resonance imaging (MRI), or fluorescence-based detection. This makes Mal-PEG6-NHS ester an essential tool for both in vivo imaging and diagnostic studies.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
