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Bis-PEG3-NHS ester is a non-cleavable 3-unit PEG linker that can be used to synthesize antibody-conjugated drugs (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00380 | -- | $-- | Inquiry |
Bis-PEG3-NHS Ester, a versatile bifunctional crosslinker, finds extensive use in biological and biomedical research. Explore its diverse applications presented with elevated perplexity and burstiness:
Protein Crosslinking: This compound serves as a cornerstone in bioconjugation experiments, facilitating the covalent linkage of proteins and peptides. Through interactions with primary amines on lysine residues, it forges stable amide bonds, enabling the formation of intricate protein complexes. This method is indispensable for investigating protein-protein interactions and constructing multifunctional protein architectures, propelling the frontiers of protein research.
Surface Modification of Biomaterials: In the realm of biomaterials, Bis-PEG3-NHS Ester plays a pivotal role in surface functionalization, empowering researchers to graft desired molecules onto biomaterial surfaces. By affixing bioactive ligands, scientists can augment cell adhesion, proliferation, and differentiation, revolutionizing applications in tissue engineering and the advancement of cutting-edge medical implants.
Drug Delivery Systems: Embracing innovation, this crosslinker is harnessed to revamp drug delivery systems, including nanoparticles and liposomes, enhancing their targeting precision and therapeutic efficacy. By coupling targeting moieties like antibodies or peptides, drug carriers are tailored for enhanced delivery to specific tissues or cells, heralding a new era of targeted therapeutics with heightened potency and reduced adverse effects.
Diagnostic Assays: In the diagnostic landscape, Bis-PEG3-NHS Ester emerges as a key player, enabling the linkage of antibodies or antigens to detection systems with finesse. By conjugating these biomolecules to labels such as enzymes or fluorophores, researchers craft sensitive and specific diagnostic assays with unparalleled precision. This technique underpins the development of ELISAs and other immunoassays, revolutionizing disease detection and monitoring with unparalleled accuracy.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
