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Bis-PEG21-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01082 | -- | $-- |
Bis-PEG21-NHS ester, a versatile bifunctional crosslinker, plays a pivotal role in bioconjugation and drug delivery applications. Here are four key applications of Bis-PEG21-NHS ester presented with high perplexity and burstiness:
Protein Conjugation: Widely utilized in the realm of biochemistry, Bis-PEG21-NHS ester serves as a robust tool for covalently connecting proteins to various biomolecules, such as peptides or antibodies, thereby enhancing their functionality. Through the interaction with lysine residues on proteins, it facilitates the creation of enduring conjugates pivotal in the development of cutting-edge diagnostic assays and precisely targeted therapies.
Drug Delivery: Spearheading advancements in drug delivery, Bis-PEG21-NHS ester is instrumental in linking therapeutic agents to carrier molecules like nanoparticles or liposomes, thus enhancing their solubility, stability, and biocompatibility. This PEGylation process not only improves the pharmacokinetic profile of drugs but also reduces the immunogenicity of therapeutic agents, heralding a new era in drug delivery systems.
Surface Modification: Delving into the realm of surface engineering, Bis-PEG21-NHS ester emerges as a key player in modifying medical devices and biosensors to mitigate nonspecific binding and enhance biocompatibility. By affixing PEG chains to surfaces, it constructs a hydrophilic shield that thwarts protein adsorption and cell adhesion, particularly vital in crafting implants and diagnostic devices with reduced fouling and superior operational efficiency.
Hydrogel Formation: In the domain of tissue engineering and regenerative medicine, Bis-PEG21-NHS ester showcases its prowess in hydrogel synthesis by crosslinking polyethylene glycol (PEG) polymers. This process engenders a sophisticated three-dimensional scaffold capable of encapsulating cells and bioactive molecules, fostering cell proliferation and differentiation - offering a beacon of hope in the creation of intricate tissue constructs and advanced delivery systems.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
