Bis-PEG7-NHS ester - CAS 1334170-02-3

Bis-PEG7-NHS ester - CAS 1334170-02-3 Catalog number: BADC-00924

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Bis-PEG7-NHS ester is a non-cleavable 7-unit PEG linker that can be used to synthesize antibody-conjugated drugs (ADCs).

Category
ADCs Linker
Product Name
Bis-PEG7-NHS ester
CAS
1334170-02-3
Catalog Number
BADC-00924
Molecular Formula
C26H40N2O15
Molecular Weight
620.60
Purity
≥95%
Bis-PEG7-NHS ester

Ordering Information

Catalog Number Size Price Quantity
BADC-00924 -- $-- Inquiry
Description
Bis-PEG7-NHS ester is a non-cleavable 7-unit PEG linker that can be used to synthesize antibody-conjugated drugs (ADCs).
Synonyms
Bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13,16,19,22-heptaoxapentacosanedioate; NHS-PEG7-NHS; 4,7,10,13,16,19,22-Heptaoxapentacosanedioic acid, 1,25-bis(2,5-dioxo-1-pyrrolidinyl) ester; α,ω-disuccinimidyl hexaethylene glycol; Di-NHS Ester-PEG7; 1,1'-[(1,25-Dioxo-4,7,10,13,16,19,22-heptaoxapentacosane-1,25-diyl)bis(oxy)]di(2,5-pyrrolidinedione); 2,5-Pyrrolidinedione, 1,1'-[(1,25-dioxo-4,7,10,13,16,19,22-heptaoxapentacosane-1,25-diyl)bis(oxy)]bis-
IUPAC Name
(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES
C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O
InChI
InChI=1S/C26H40N2O15/c29-21-1-2-22(30)27(21)42-25(33)5-7-35-9-11-37-13-15-39-17-19-41-20-18-40-16-14-38-12-10-36-8-6-26(34)43-28-23(31)3-4-24(28)32/h1-20H2
InChIKey
QWDCSPQIVZTPRD-UHFFFAOYSA-N
Density
1.3±0.1 g/cm3
Solubility
Soluble in DCM, DMF, DMSO
Appearance
Colorless or Light Yellowish Liquid
Shelf Life
-20°C 3 years powder; -80°C 2 years in solvent
Shipping
Room temperature
Storage
Store at 2-8°C
Boiling Point
685.8±65.0°C at 760 mmHg

Bis-PEG7-NHS ester is a crosslinking reagent widely used in bioconjugation and chemical biology. Here are some key applications of Bis-PEG7-NHS ester:

Protein-Protein Conjugation: Bis-PEG7-NHS ester is commonly used to link two proteins together, forming stable protein-protein conjugates. This technique is essential for creating bifunctional proteins for research and therapeutic purposes. It allows for the study of protein interactions and the development of multi-functional biotherapeutics.

Antibody-Drug Conjugates (ADCs): In the development of targeted cancer therapies, Bis-PEG7-NHS ester is used to attach cytotoxic drugs to antibodies. By forming a stable linker between the drug and the antibody, it ensures targeted delivery of the drug to cancer cells, minimizing off-target effects. This technology is pivotal for enhancing the efficacy and specificity of cancer treatments.

Surface Modification: Bis-PEG7-NHS ester is utilized to modify surfaces of various materials, such as nanoparticles, glass, and polymers. By attaching functional groups to surfaces, it enhances biocompatibility, reduces non-specific binding, and improves the stability of biomedical devices. This application is critical for the development of biosensors, implants, and diagnostic tools.

Peptide Synthesis: In peptide synthesis, Bis-PEG7-NHS ester is employed to link peptides together or to attach peptides to other molecules. This crosslinking is crucial for creating peptide arrays, peptide-based drugs, and for studying peptide interactions. It enables the design of complex peptide structures with improved stability and functionality.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Bis-PEG7-NHS ester
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