Bis-PEG25-NHS ester - CAS 2221948-96-3

Bis-PEG25-NHS ester - CAS 2221948-96-3 Catalog number: BADC-01081

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Bis-PEG25-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
Bis-PEG25-NHS ester
CAS
2221948-96-3
Catalog Number
BADC-01081
Molecular Formula
C14H16N2O10
Molecular Weight
372.28
Bis-PEG25-NHS ester

Ordering Information

Catalog Number Size Price Quantity
BADC-01081 -- $--
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Description
Bis-PEG25-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
NHS-PEG24-NHS
IUPAC Name
(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES
C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O
InChI
InChI=1S/C62H112N2O33/c65-57-1-2-58(66)63(57)96-61(69)5-7-71-9-11-73-13-15-75-17-19-77-21-23-79-25-27-81-29-31-83-33-35-85-37-39-87-41-43-89-45-47-91-49-51-93-53-55-95-56-54-94-52-50-92-48-46-90-44-42-88-40-38-86-36-34-84-32-30-82-28-26-80-24-22-78-20-18-76-16-14-74-12-10-72-8-6-62(70)97-64-59(67)3-4-60(64)68/h1-56H2
InChIKey
JPTYKIPGEDAOCK-UHFFFAOYSA-N
Solubility
10 mm in DMSO
Appearance
Solid
Purity
>98.0%
Shelf Life
-20°C 3 years powder; -80°C 2 years in solvent
Shipping
Room temperature
Storage
-20°C
Form
Solid

Bis-PEG25-NHS ester, a multifaceted bifunctional polyethylene glycol (PEG) derivative, boasts extensive applications in bioconjugation and cross-linking. Dive into four key applications of Bis-PEG25-NHS ester presented with a high degree of perplexity and burstiness:

Protein Modification: Through the strategic utilization of Bis-PEG25-NHS ester, researchers can intricately modify proteins via PEGylation, a sophisticated process entailing the attachment of PEG chains. These intricately intertwined chains not only augment the solubility, stability, and biocompatibility of proteins but also mitigate immunogenicity and proteolytic degradation. This cutting-edge technique serves as a cornerstone in the realm of protein-based drugs and therapeutic enzymes, heralding a new era of advanced therapeutic formulations.

Nanoparticle Surface Functionalization: Serving as a linchpin in the functionalization of nanoparticle surfaces, Bis-PEG25-NHS ester plays a critical role in enhancing their dispersibility and stability within biological environments. Surface modification with PEG chains serves to minimize nonspecific interactions and extend circulation time in the bloodstream, a pivotal factor in the efficient delivery of drugs and imaging agents in the burgeoning field of nanomedicine.

Hydrogel Formation: In the domain of biomaterials, Bis-PEG25-NHS ester emerges as a pivotal player in the synthesis of hydrogels by intricately cross-linking polymer chains. These meticulously crafted hydrogels, finely tuned through the cross-linking process, exhibit tailored mechanical properties and biocompatibility, rendering them ideal for a myriad of biomedical applications, including tissue engineering and wound healing. The meticulous control over cross-linking endows researchers with the ability to customize the physical attributes of the hydrogel for optimized performance.

Biosensor Development: Within the intricate realm of biosensor technology, Bis-PEG25-NHS ester assumes a critical role in immobilizing biomolecules such as antibodies and enzymes onto sensor surfaces. The resultant PEGylated surfaces exhibit remarkable resistance to protein adsorption, thereby diminishing background noise and amplifying sensor specificity. This groundbreaking advancement translates into heightened accuracy and reliability in detecting analytes, indispensable for diagnostic assays and environmental monitoring endeavors.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Fmoc-PEA | Bis-PEG25-NHS ester
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