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Bis-PEG25-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01081 | -- | $-- | Inquiry |
Bis-PEG25-NHS ester, a multifaceted bifunctional polyethylene glycol (PEG) derivative, boasts extensive applications in bioconjugation and cross-linking. Dive into four key applications of Bis-PEG25-NHS ester presented with a high degree of perplexity and burstiness:
Protein Modification: Through the strategic utilization of Bis-PEG25-NHS ester, researchers can intricately modify proteins via PEGylation, a sophisticated process entailing the attachment of PEG chains. These intricately intertwined chains not only augment the solubility, stability, and biocompatibility of proteins but also mitigate immunogenicity and proteolytic degradation. This cutting-edge technique serves as a cornerstone in the realm of protein-based drugs and therapeutic enzymes, heralding a new era of advanced therapeutic formulations.
Nanoparticle Surface Functionalization: Serving as a linchpin in the functionalization of nanoparticle surfaces, Bis-PEG25-NHS ester plays a critical role in enhancing their dispersibility and stability within biological environments. Surface modification with PEG chains serves to minimize nonspecific interactions and extend circulation time in the bloodstream, a pivotal factor in the efficient delivery of drugs and imaging agents in the burgeoning field of nanomedicine.
Hydrogel Formation: In the domain of biomaterials, Bis-PEG25-NHS ester emerges as a pivotal player in the synthesis of hydrogels by intricately cross-linking polymer chains. These meticulously crafted hydrogels, finely tuned through the cross-linking process, exhibit tailored mechanical properties and biocompatibility, rendering them ideal for a myriad of biomedical applications, including tissue engineering and wound healing. The meticulous control over cross-linking endows researchers with the ability to customize the physical attributes of the hydrogel for optimized performance.
Biosensor Development: Within the intricate realm of biosensor technology, Bis-PEG25-NHS ester assumes a critical role in immobilizing biomolecules such as antibodies and enzymes onto sensor surfaces. The resultant PEGylated surfaces exhibit remarkable resistance to protein adsorption, thereby diminishing background noise and amplifying sensor specificity. This groundbreaking advancement translates into heightened accuracy and reliability in detecting analytes, indispensable for diagnostic assays and environmental monitoring endeavors.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
