Bis-PEG17-NHS ester - CAS 2221948-93-0

Bis-PEG17-NHS ester - CAS 2221948-93-0 Catalog number: BADC-01080

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Bis-PEG17-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
Bis-PEG17-NHS ester
CAS
2221948-93-0
Catalog Number
BADC-01080
Molecular Formula
C46H80N2O25
Molecular Weight
1061.13
Purity
>98.0%
Bis-PEG17-NHS ester

Ordering Information

Catalog Number Size Price Quantity
BADC-01080 -- $-- Inquiry
Description
Bis-PEG17-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
NHS-PEG16-NHS
IUPAC Name
(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES
C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O
InChI
InChI=1S/C46H80N2O25/c49-41-1-2-42(50)47(41)72-45(53)5-7-55-9-11-57-13-15-59-17-19-61-21-23-63-25-27-65-29-31-67-33-35-69-37-39-71-40-38-70-36-34-68-32-30-66-28-26-64-24-22-62-20-18-60-16-14-58-12-10-56-8-6-46(54)73-48-43(51)3-4-44(48)52/h1-40H2
InChIKey
NKGAYEIPIYDEJM-UHFFFAOYSA-N
Solubility
10 mm in DMSO
Appearance
Solid
Shelf Life
-20°C 3 years powder; -80°C 2 years in solvent
Shipping
Room temperature
Storage
-20°C
Form
Solid

Bis-PEG17-NHS ester is a bifunctional polyethylene glycol (PEG) derivative commonly used in bioconjugation and surface modification applications. Here are some key applications of Bis-PEG17-NHS ester:

Protein Pegylation: Bis-PEG17-NHS ester is used to modify proteins by attaching PEG chains to lysine residues. This process, known as pegylation, enhances the stability, solubility, and half-life of therapeutic proteins. By reducing immunogenicity and proteolytic degradation, pegylation improves the overall efficacy of protein-based drugs.

Surface Functionalization: In sensor technologies and bioassays, Bis-PEG17-NHS ester is employed to immobilize biomolecules on solid surfaces. By linking PEG molecules to biosensors or microarrays, it creates a biocompatible and non-fouling surface. This enhances the performance and accuracy of diagnostic assays by reducing non-specific binding.

Nanoparticle Modification: Bis-PEG17-NHS ester is used to coat nanoparticles with PEG chains, providing a hydrophilic and stealthy layer. This modification reduces opsonization and prolongs the circulation time of nanoparticles in the bloodstream. It’s particularly beneficial for drug delivery systems as it enhances the targeting efficiency and bioavailability of the therapeutic agents.

Tissue Engineering: Bis-PEG17-NHS ester is utilized in the development of hydrogels and scaffolds for tissue engineering applications. By crosslinking with amino groups in the scaffold matrix, it increases the mechanical strength and stability of the constructs. This supports the growth and differentiation of cells, facilitating tissue regeneration and repair.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: JUN68744 | Bis-PEG17-NHS ester
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