Inquiry Basket
Mal-PEG3-NHS ester is a non-cleavable ADC linker containing the Maleimide group. It can be used to prepare antibody conjugated drugs (ADCs).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-00603 | -- | $-- | Inquiry |
Mal-PEG3-NHS ester, a versatile chemical reagent in bioconjugation with diverse applications in bioscience and biotechnology, is a key player in various domains.
Protein Modification: Through the intricate process of PEGylation, Mal-PEG3-NHS ester assumes a crucial role in the modification of proteins by the addition of polyethylene glycol (PEG) chains to their surfaces. This modification significantly boosts protein stability, solubility, and in vivo half-life, establishing itself as a cornerstone in therapeutic protein development. The selective conjugation of PEG to lysine residues on proteins via the NHS ester group allows for targeted enhancements of their properties.
Antibody Conjugation: In addition to its role in protein modification, Mal-PEG3-NHS ester facilitates the conjugation of antibodies with diverse molecules like fluorescent dyes or drug compounds, paving the way for groundbreaking diagnostic applications and precise targeted therapy. The maleimide group within this compound exhibits specificity in reacting with thiol groups, enabling site-specific labeling of antibody fragments. This tailored conjugation strategy plays a pivotal role in the evolution of antibody-drug conjugates (ADCs) and the refinement of diagnostic assays with unparalleled accuracy.
Surface Coating: Leveraging its unique properties, Mal-PEG3-NHS ester emerges as an indispensable tool for surface coating applications aimed at reducing non-specific binding and enhancing biocompatibility across a spectrum of biomedical devices. By establishing PEGylated layers on surfaces, researchers create barriers to protein adsorption and cell adhesion, a strategic approach widely embraced in the design of biosensors, microarrays, and implantable devices to optimize performance and safety through tailored modifications.
Cellular Imaging: In the domain of cellular imaging, the versatility of Mal-PEG3-NHS ester shines brightly, facilitating the conjugation of imaging probes to biomolecules for unrivaled visualization of specific proteins and cellular components. This precise labeling assists researchers in delving into dynamic cellular processes and intricate protein interactions using cutting-edge imaging modalities like fluorescence microscopy.
Customer Support
Providing excellent 24/7 customer service and support
Project Management
Offering 100% high-quality services at all stages
Quality Assurance
Ensuring the quality and reliability of products or services
Global Delivery
Ensuring timely delivery of products worldwide
BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
