Inquiry Basket
Mal-PEG4-NHS is a non-cleavable ADC linker containing the Maleimide group, 4-unit PEG, and NHS ester.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00450 | -- | $-- | Inquiry |
Mal-PEG4-NHS is a highly reactive bioconjugation reagent used extensively in drug delivery, protein labeling, and targeted therapies. The maleimide (Mal) group facilitates efficient conjugation with thiol-containing molecules, such as peptides, proteins, and antibodies, while the NHS (N-hydroxysuccinimide) ester reacts with primary amines, allowing for versatile functionalization. The PEG4 spacer provides enhanced solubility, stability, and pharmacokinetics, improving the conjugate’s in vivo performance. This compound is widely used in the design of antibody-drug conjugates (ADCs), targeted delivery systems, and biomolecule labeling for research and therapeutic applications.
A key application of Mal-PEG4-NHS is in the development of antibody-drug conjugates (ADCs) for cancer therapy. By linking cytotoxic drugs or therapeutic agents to monoclonal antibodies through the maleimide group, this conjugate enables the selective delivery of drugs to tumor cells that express specific surface antigens. The PEG4 spacer improves the pharmacokinetics of the conjugate, increasing its solubility and circulation time, which ensures better distribution throughout the body. The NHS ester allows for the addition of targeting ligands or further functionalization with other biomolecules, such as imaging agents, for dual-targeting or monitoring of therapeutic efficacy. This targeted approach improves the therapeutic index by enhancing the drug’s efficacy at the tumor site while minimizing off-target effects.
Mal-PEG4-NHS is also widely used in protein and peptide labeling for research and diagnostic applications. The NHS ester reacts with primary amines on proteins, peptides, or other biomolecules, enabling the covalent attachment of fluorescent dyes, enzymes, or other functional groups. The PEG4 spacer ensures that the conjugated biomolecule maintains solubility and stability in aqueous environments, reducing aggregation and improving its overall functionality. This makes Mal-PEG4-NHS an ideal reagent for applications in flow cytometry, immunoassays, and live-cell imaging, where precise labeling of biomolecules is critical for tracking cellular processes or studying molecular interactions.
Another important application of Mal-PEG4-NHS is in the creation of targeted drug delivery systems. By conjugating therapeutic agents to targeting ligands, such as antibodies or peptides, via the NHS ester, Mal-PEG4-NHS enables the specific delivery of drugs to designated cells or tissues. The PEG4 spacer enhances the pharmacokinetics and bioavailability of the conjugate, ensuring better drug release profiles and reducing systemic toxicity. This approach is particularly useful in the development of personalized medicine, where drugs can be tailored to target specific molecular markers or receptors found on cancer cells or other diseased tissues, providing more effective treatment options.
Customer Support
Providing excellent 24/7 customer service and support
Project Management
Offering 100% high-quality services at all stages
Quality Assurance
Ensuring the quality and reliability of products or services
Global Delivery
Ensuring timely delivery of products worldwide
BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
