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| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01020 | -- | $-- |
Boc-Val-Ala-PAB-PNP is a synthetic compound belonging to the class of prodrugs, which are pharmacologically inactive substances that undergo in vivo conversion to active drugs.
In terms of biochemical applications, Boc-Val-Ala-PAB-PNP is predominantly explored for its potential in targeted drug delivery systems. This prodrug is designed to be stable in the bloodstream, preventing premature activation, and to be selectively activated at the target site. The ester-linked PNP component is particularly significant because it serves as a leaving group that can be cleaved in response to specific enzymatic activity or environmental conditions present in pathological sites, such as tumors. Consequently, Boc-Val-Ala-PAB-PNP can be used to deliver anticancer drugs directly to cancerous tissues, thereby maximizing therapeutic efficacy while minimizing systemic toxicity. This targeted approach is especially advantageous in reducing adverse side effects commonly associated with conventional chemotherapy.
Beyond oncology, another notable application of Boc-Val-Ala-PAB-PNP lies in its use as a biochemical tool in research and diagnostic applications. The controlled release of active pharmaceutical ingredients (APIs) facilitated by this prodrug can be leveraged in various experimental settings to study drug interactions, pharmacokinetics, and pharmacodynamics in a controlled manner. Furthermore, the PNP component, upon release, can be used in colorimetric assays due to its yellow coloration, aiding in the visual quantification of enzyme activities or chemical reactions. This versatile nature makes Boc-Val-Ala-PAB-PNP not only a valuable drug delivery system but also a useful compound in research laboratories focused on drug development and disease mechanisms.
Moreover, the synthesis process of Boc-Val-Ala-PAB-PNP is associated with the advancement of synthetic chemistry techniques, including solid-phase peptide synthesis (SPPS) and chemical conjugation methods. These techniques facilitate the efficient and scalable production of peptide-based prodrugs, allowing for the exploration of various amino acid sequences to modify the pharmacokinetic and pharmacodynamic profiles of the resulting compounds. The adaptability of the synthesis process encourages further research into developing tailored prodrugs, thereby opening new frontiers in personalized medicine. As a result, Boc-Val-Ala-PAB-PNP is not only a subject of scientific investigation for its direct applications but also for the methodological advancements it promotes within the pharmaceutical chemistry field.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
