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Boc-Val-Ala-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01647 | -- | $-- | Inquiry |
Boc-Val-Ala-PAB, a synthetic molecule commonly applied in peptide synthesis and drug delivery, carries significant importance in various fields.
Peptide Synthesis: A pivotal component in synthesizing peptides, Boc-Val-Ala-PAB serves as a crucial building block. Acting as a shield for amino acids, it safeguards against unwanted reactions during peptide assembly, ensuring the purity and yield vital for subsequent research and therapeutic usage. This protective role plays a critical part in the synthesis process, guaranteeing the integrity of the peptides formed.
Drug Delivery Systems: Within drug delivery systems, Boc-Val-Ala-PAB plays a dual role in enhancing stability and amplifying the effectiveness of therapeutic compounds. Its integration into prodrugs acts as a shield, safeguarding the active pharmaceutical ingredient until it reaches its intended destination. This integration not only enhances bioavailability but also diminishes the adverse effects associated with medications, offering a more targeted and efficient treatment approach.
Protease Substrate Design: In the realm of studying protease activity, Boc-Val-Ala-PAB plays a pivotal role in substrate design. With a specific sequence tailored for recognition and cleavage by select proteases, it proves invaluable in biochemical assays. This application stands as a cornerstone in unraveling protease functionalities and lays the groundwork for the development of protease inhibitors with potential as pharmaceutical candidates, showcasing its multifaceted utility in research and drug development.
Anticancer Research: Researchers leverage Boc-Val-Ala-PAB as a fundamental linker in crafting antibody-drug conjugates (ADCs). These conjugates fuse antibody-targeting precision with small molecule cytotoxicity, facilitating targeted delivery of anticancer agents specifically to tumor cells. By facilitating controlled drug release, Boc-Val-Ala-PAB maximizes therapeutic efficacy while simultaneously minimizing harm to healthy tissues, underscoring its pivotal role in cutting-edge anticancer research and treatment innovations.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
