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Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00983 | -- | $-- |
Azido-PEG2-amine, a versatile compound utilized in bioconjugation and biochemistry, holds vast potential for diverse applications. Here are four key applications of Azido-PEG2-amine, conveyed with elevated levels of perplexity and burstiness:
Click Chemistry: Embraced in the realm of click chemistry, Azido-PEG2-amine serves as a linchpin for bioorthogonal labeling and conjugation reactions. The azide group intricately interacts with alkyne-containing molecules via the Huisgen cycloaddition, culminating in the formation of stable triazole linkages. This transformative chemistry enables the precise and selective attachment of biomolecules for a spectrum of uses, spanning from diagnostic imaging to therapeutic interventions.
Drug Delivery Systems: Within the realm of pharmaceutical innovation, Azido-PEG2-amine plays a pivotal role in enhancing drug delivery systems by improving solubility and biocompatibility. The integration of the PEG segment elevates the drug's pharmacokinetics by augmenting its hydrophilicity and prolonging its circulation time in the bloodstream. Leveraging the azido group for further functionalization allows for the conjugation of therapeutic agents, thereby enabling targeted and efficacious drug delivery strategies.
Protein Modification: In the dynamic domain of proteomics, Azido-PEG2-amine emerges as a key player in protein modification through site-specific labeling. By introducing the azide group into proteins using either chemical or enzymatic approaches, researchers pave the way for subsequent conjugation with alkyne-tagged probes. This methodology empowers scientists to delve into protein interactions, monitor localization, and track post-translational modifications with precision and depth.
Surface Functionalization: Azido-PEG2-amine finds its niche in the field of surface functionalization, where it contributes to enhancing the properties of nanoparticles, biosensors, and biomaterials. The strategic coupling of the azide group with alkyne-modified surfaces results in the creation of biocompatible coatings, thereby bolstering the performance of materials. This heightened functionality opens up new avenues for applications in medical devices, tissue engineering, and diagnostic tools, ushering in a wave of innovation and advancement in diverse sectors.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
