CbzNH-PEG8-amide-bis(pentayl-5OBz)

CbzNH-PEG8-amide-bis(pentayl-5OBz) Catalog number: BADC-01878

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CbzNH-PEG8-amide-bis(pentayl-5OBz) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
CbzNH-PEG8-amide-bis(pentayl-5OBz)
Catalog Number
BADC-01878
Molecular Formula
C114H118N4O33
Molecular Weight
2072.16

Ordering Information

Catalog Number Size Price Quantity
BADC-01878 -- $--
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Description
CbzNH-PEG8-amide-bis(pentayl-5OBz) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
IUPAC Name
[(2S,3S,4S,5R)-2,3,4,5-tetrabenzoyloxy-6-[[(4S)-5-oxo-5-[[(2S,3R,4R,5R)-2,3,4,5,6-pentabenzoyloxyhexyl]amino]-4-[3-[2-[2-[2-[2-[2-[2-[2-[2-(phenylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]pentanoyl]amino]hexyl] benzoate
Canonical SMILES
C1=CC=C(C=C1)COC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)NC(CCC(=O)NCC(C(C(C(COC(=O)C2=CC=CC=C2)OC(=O)C3=CC=CC=C3)OC(=O)C4=CC=CC=C4)OC(=O)C5=CC=CC=C5)OC(=O)C6=CC=CC=C6)C(=O)NCC(C(C(C(COC(=O)C7=CC=CC=C7)OC(=O)C8=CC=CC=C8)OC(=O)C9=CC=CC=C9)OC(=O)C1=CC=CC=C1)OC(=O)C1=CC=CC=C1
InChI
InChI=1S/C114H118N4O33/c119-97(116-76-93(144-106(124)84-40-18-4-19-41-84)99(148-110(128)88-48-26-8-27-49-88)101(150-112(130)90-52-30-10-31-53-90)95(146-108(126)86-44-22-6-23-45-86)79-141-104(122)82-36-14-2-15-37-82)57-56-92(118-98(120)58-60-133-62-64-135-66-68-137-70-72-139-74-75-140-73-71-138-69-67-136-65-63-134-61-59-115-114(132)143-78-81-34-12-1-13-35-81)103(121)117-77-94(145-107(125)85-42-20-5-21-43-85)100(149-111(129)89-50-28-9-29-51-89)102(151-113(131)91-54-32-11-33-55-91)96(147-109(127)87-46-24-7-25-47-87)80-142-105(123)83-38-16-3-17-39-83/h1-55,92-96,99-102H,56-80H2,(H,115,132)(H,116,119)(H,117,121)(H,118,120)/t92-,93+,94-,95-,96+,99-,100+,101-,102+/m0/s1
InChIKey
CIDVENIIHKNHNM-NUETZRLOSA-N

CbzNH-PEG8-amide-bis(pentayl-5OBz) is a sophisticated compound characterized by its multifunctional capabilities and versatility in biochemical applications. The compound consists of a core structure of CbzNH-PEG8-amide linked with bis(pentayl-5OBz) units, offering unique properties enabled by its intricate molecular architecture. The CbzNH-PEG8 segment provides enhanced solubility and reduced immunogenicity, making it valuable in bioconjugation and drug delivery applications. The bis(pentayl-5OBz) component, on the other hand, contributes to the compound’s stability and reactivity, essential for effective therapeutic and diagnostic uses.

One of the primary applications of CbzNH-PEG8-amide-bis(pentayl-5OBz) is in targeted drug delivery systems. The PEGylated structure enhances the pharmacokinetics of therapeutic agents, allowing for prolonged circulation time in the bloodstream and improved penetration into target tissues. This property is particularly valuable in oncology, where precise delivery of chemotherapy drugs to cancer cells can significantly enhance treatment efficacy while minimizing side effects. The compound’s chemical stability ensures that the drug remains intact until it reaches the intended site, maximizing therapeutic outcomes.

Another critical application is in the development of diagnostic imaging agents. CbzNH-PEG8-amide-bis(pentayl-5OBz) can be utilized to create contrast agents for MRI and other imaging modalities. Its biocompatible and hydrophilic nature allows it to circulate efficiently in the body without eliciting adverse immune responses. By conjugating with various imaging molecules, it provides enhanced visualization of internal structures, aiding in early disease detection and monitoring the progression of medical conditions. This functionality is pivotal in tailoring personalized treatment plans and improving patient outcomes.

Furthermore, CbzNH-PEG8-amide-bis(pentayl-5OBz) exhibits potential in the field of regenerative medicine. The compound’s ability to facilitate cell adhesion and proliferation makes it a promising candidate for tissue engineering applications. By supporting the growth and differentiation of stem cells, it can aid in the repair and regeneration of damaged tissues, offering hope for patients with conditions that currently lack effective treatments. Its role in scaffolding materials used in regenerative medicine is indicative of its transformative potential in healthcare.

Lastly, the compound holds promise in creating biosensors for environmental and clinical applications. CbzNH-PEG8-amide-bis(pentayl-5OBz) can be engineered to detect specific biological or chemical signals with high sensitivity and specificity. These biosensors can be used for detecting disease biomarkers, environmental pollutants, or pathogens, providing rapid and reliable data for decision-making in various fields. Its integration into smart diagnostic tools aligns with the growing trend of personalized medicine and the need for real-time monitoring solutions.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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