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Cyclooctyne-O-amido-PEG3-NHS ester is a valuable compound used in the biomedical industry for bioconjugation purposes. It acts as a versatile crosslinker for labeling and modification of biomolecules, such as proteins and antibodies. With its NHS ester functionality, it enables efficient and stable conjugation to primary amines. It finds applications in drug delivery systems, diagnostics, and targeted therapeutics, contributing to advancements in treating various diseases.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01532 | -- | $-- | Inquiry |
Cyclooctyne-O-amido-PEG3-NHS ester, a versatile reagent in bioconjugation applications, excels in enabling precise and efficient coupling of biomolecules. Here are four key applications of this compound:
Site-Specific Protein Labeling: Harnessing Cyclooctyne-O-amido-PEG3-NHS ester, researchers can intricately label proteins at specific sites by interacting with amino groups on the protein surface. This technique facilitates the attachment of a wide array of probes or tags, crucial for in-depth scrutiny of protein interactions, localization, and function, while preserving the protein’s inherent activity.
Antibody-Drug Conjugates (ADCs): Within the domain of ADC synthesis, this reagent serves as a vital linker, connecting antibodies to cytotoxic drugs. Featuring a PEG3 spacer, it ensures optimal spacing and solubility, thereby enhancing the efficacy and stability of the conjugate. ADCs, pivotal in targeted cancer therapies, deliver drugs directly to tumor cells, minimizing undesirable off-target effects and revolutionizing treatment strategies.
Nanoparticle Functionalization: Playing a pivotal role in nanoparticle functionalization, Cyclooctyne-O-amido-PEG3-NHS ester facilitates the attachment of targeting ligands or therapeutics onto nanoparticles by reacting with surface amines. The NHS ester enables stable attachment of biomolecules, driving advancements in the development of targeted drug delivery systems and state-of-the-art diagnostic tools, propelling the field of nanomedicine forward.
Bioorthogonal Click Chemistry: Serving as a cornerstone of bioorthogonal click chemistry, this reagent enables selective and rapid reactions within biological systems. Its strained cyclooctyne group engages in copper-free click reactions with azides, allowing for in vivo labeling and imaging. This technique plays a crucial role in studying dynamic biological processes and tracking molecular interactions in live cells and organisms, offering valuable insights into the intricate workings of biological systems.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
