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Cyclooctyne-O-amido-PEG2-PFP ester is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01061 | -- | $-- | Inquiry |
Cyclooctyne-O-amido-PEG2-PFP ester, a highly versatile reagent utilized in bioconjugation and click chemistry, offers a myriad of applications. Here are four key applications of this reagent presented with elevated perplexity and burstiness:
Protein Labeling: Harnessing the power of Cyclooctyne-O-amido-PEG2-PFP ester, researchers can intricately label proteins with fluorescent dyes or other tags. This reagent facilitates the precise attachment of labels to proteins through strain-promoted azide-alkyne cycloaddition (SPAAC) reactions, enabling the creation of labeled proteins essential for advanced imaging, tracking, and studying protein dynamics within live cells.
Drug Delivery: Cyclooctyne-O-amido-PEG2-PFP ester plays a crucial role in conjugating therapeutic agents to targeting molecules, such as antibodies or ligands, allowing for targeted drug delivery to specific cells or tissues. By enhancing therapeutic efficacy while minimizing off-target effects, these bioconjugates are at the forefront of developing precision-targeted cancer therapies.
Surface Functionalization: Delving into the realm of surface modification, Cyclooctyne-O-amido-PEG2-PFP ester is employed to enhance biomaterials or medical devices. By attaching bioactive molecules or antifouling agents to surfaces, researchers can amplify the biocompatibility and functionality of implants, sensors, and other medical devices, paving the way for advanced biomedical technologies with heightened performance and efficacy.
Molecular Imaging: Positioned at the intersection of science and innovation, Cyclooctyne-O-amido-PEG2-PFP ester is instrumental in crafting imaging probes for diagnostic applications. By conjugating biocompatible imaging agents to targeting moieties through cyclooctyne-based chemistry, researchers can develop probes for PET, MRI, or optical imaging, enabling non-invasive visualization of molecular processes and disease states within the body.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
