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Cyclooctyne-O-amido-PEG4-PFP ester is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01240 | -- | $-- |
Cyclooctyne-O-amido-PEG4-PFP ester, a versatile reagent in bioconjugation and chemical biology, finds diverse applications in various fields. Here are four key applications:
Bioorthogonal Chemistry: Serving as a cornerstone in bioorthogonal chemistry, Cyclooctyne-O-amido-PEG4-PFP ester enables specific and rapid conjugation reactions within living systems, seamlessly interfacing with native biochemical processes. This reagent excels in labeling biomolecules amidst the intricacies of complex biological environments, offering a window into real-time dynamic processes unfolding within living cells and organisms.
Protein Labeling: Embracing the realm of protein labeling, this compound selectively decorates proteins with diverse probes or tags, amplifying their detectability and facilitating in-depth analysis. The PEG4 linker, boasting solubility and reducing steric obstructions, enhances the labeling process’s efficiency. Protein labeling, a linchpin in techniques like fluorescence microscopy, Western blotting, and mass spectrometry, unveils hidden aspects of cellular machinery.
Drug Delivery Systems: In crafting targeted drug delivery systems, Cyclooctyne-O-amido-PEG4-PFP ester emerges as a game-changer, conjugating therapeutic agents to targeting molecules such as antibodies or peptides. This strategic coupling ensures precise drug delivery to afflicted cells, minimizing collateral damage and boosting therapeutic potency. Its impact shines in the realm of cancer therapy, wherein pinpoint accuracy can revolutionize treatment outcomes.
Diagnostics: Unveiling latent potential in diagnostics, this reagent bolsters the development of diagnostic assays and imaging agents. By hitching onto specific biomolecules, it elevates the sensitivity and specificity of diagnostic tests. This application stands tall in critical domains like medical diagnostics and molecular imaging, where accurate biomarker detection spells the difference between swift disease diagnosis and effective monitoring.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
