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DBCO-PEG4-GGFG-DMEA-PNU159682 is a click-reactive drug-linker conjugate used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01421 | -- | $-- | Inquiry |
DBCO-PEG4-GGFG-DMEA-PNU159682, a versatile compound with multifaceted applications in research and therapeutic advancement, is a cornerstone in various scientific fields.
Click Chemistry: Widely embraced in click chemistry, DBCO-PEG4-GGFG-DMEA-PNU159682 plays a pivotal role in bioconjugation endeavors. The reactive DBCO moiety swiftly interacts with azide groups, facilitating the precise labeling and modification of biomolecules. This click reaction, characterized by remarkable efficiency, operates seamlessly under gentle conditions, making it a prime choice for live-cell imaging and protein-tagging investigations.
Drug Delivery: Boasting a PEG4 spacer, DBCO-PEG4-GGFG-DMEA-PNU159682 enhances solubility and stability, a boon for drug delivery applications. By conjugating it with therapeutic agents, researchers optimize the pharmacokinetics and biodistribution of drugs, enabling targeted delivery of potent anticancer medications like PNU159682. This targeted approach not only diminishes adverse effects but also enhances therapeutic outcomes significantly.
Protease-Responsive Prodrugs: The GGFG linker, a discernible peptide sequence susceptible to specific proteases, endows DBCO-PEG4-GGFG-DMEA-PNU159682 with invaluable utility in prodrug development. Following cleavage by target proteases in the tumor microenvironment, the potent drug PNU159682 is liberated. This strategic design allows for precise activation of drugs at the intended site, mitigating systemic toxicity and amplifying therapeutic efficacy.
Bioorthogonal Labeling: Positioned as a key player in bioorthogonal labeling, DBCO-PEG4-GGFG-DMEA-PNU159682 facilitates the labeling of biomolecules in intricate biological systems. The DBCO group selectively engages with azide-functionalized probes without disrupting natural cellular processes. This precision enables meticulous tracking and visualization of biomolecules in live-cell assays and in vivo studies, facilitating cutting-edge research in cell biology and molecular imaging.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
