Catalog Number | Size | Price | Quantity |
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BADC-01257 | -- | $-- |
DBCO-Val-Cit-PABC-PNP is a compound used in bioconjugation and drug delivery applications, exploiting its unique chemical and biological properties. Here are some key applications of DBCO-Val-Cit-PABC-PNP:
Antibody-Drug Conjugates (ADCs): DBCO-Val-Cit-PABC-PNP is commonly used in the synthesis of antibody-drug conjugates, where it serves as a linker to attach cytotoxic drugs to antibodies. This enables the targeted delivery of chemotherapy agents specifically to cancer cells, minimizing off-target effects and improving therapeutic efficacy. The stability and cleavability of the Val-Cit linker ensure the release of the drug within the tumor microenvironment.
Click Chemistry: The DBCO moiety in DBCO-Val-Cit-PABC-PNP makes it an ideal reagent for click chemistry reactions, particularly in bioorthogonal conjugation. This allows for the specific and efficient labeling of biomolecules in a controlled manner, facilitating the study of complex biological systems. The use of click chemistry with DBCO-Val-Cit-PABC-PNP is highly valuable in proteomics, cell imaging, and diagnostics.
Targeted Drug Delivery: By incorporating DBCO-Val-Cit-PABC-PNP into prodrug systems, researchers can achieve targeted drug delivery with precise control over drug activation. The Val-Cit dipeptide linker is enzymatically cleavable, ensuring the release of the active drug in specific cellular environments, such as tumor tissues. This strategy enhances the therapeutic index and reduces the systemic toxicity of potent drugs.
Bioconjugation: DBCO-Val-Cit-PABC-PNP is extensively utilized in bioconjugation for tagging and modifying proteins, peptides, and other biomolecules. The DBCO group allows for robust and selective conjugation to azide-functionalized molecules under mild conditions. This application is critical in the development of novel biotherapeutics, biosensors, and in various diagnostic procedures.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.