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| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01342 | -- | $-- | Inquiry |
DBCO-C4-Val-Cit-PABC-PNP, a versatile chemical reagent, plays a pivotal role in targeted drug delivery and bioconjugation. Here are four key applications of this compound:
Antibody-Drug Conjugates (ADCs): At the forefront of cancer therapy, DBCO-C4-Val-Cit-PABC-PNP is extensively utilized in crafting antibody-drug conjugates. By linking a cytotoxic drug to an antibody through this versatile linker, targeted delivery to cancer cells is accomplished. This strategy not only amplifies therapeutic effectiveness but also mitigates harm to normal tissues, marking a breakthrough in precision medicine.
Click Chemistry: In the realm of bioorthogonal chemistry, this reagent shines in facilitating stable covalent bonds between biomolecules. Its strain-promoted alkyne-azide cycloaddition (SPAAC) capability enables specific and efficient linking without the need for a catalyst. This feature proves invaluable in labeling biomolecules for imaging or functional investigations, opening new avenues for innovative research in molecular biology.
Controlled Drug Release: Engineered for precision, DBCO-C4-Val-Cit-PABC-PNP responds to specific enzymes like cathepsin B, prevalent in tumor microenvironments. This unique attribute allows for the precise release of therapeutic agents directly at the designated target site, curtailing systemic side effects and optimizing drug efficacy. Such tailored drug delivery heralds a paradigm shift in cancer treatment.
Protein Modification: In the realm of protein engineering and biotechnology, this reagent serves as a cornerstone for protein modification with minimal perturbation to their native function. By conjugating therapeutic moieties or other functional groups to proteins, novel functionalities can be conferred, paving the way for advanced biopharmaceuticals and diagnostic tools. This innovative application underscores the transformative potential of DBCO-C4-Val-Cit-PABC-PNP in shaping the future of biotechnology.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
