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Fmoc-Ala-Ala-Asn(Trt)-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01025 | -- | $-- |
Fmoc-Ala-Ala-Asn(Trt)-OH, a protected tripeptide crucial in peptide and protein synthesis, offers a multitude of applications:
Peptide Synthesis: In the realm of solid-phase peptide synthesis (SPPS), Fmoc-Ala-Ala-Asn(Trt)-OH plays a pivotal role in crafting custom peptides. Its Fmoc group shields the amino terminus throughout synthesis, ensuring precise elongation of the peptide chain. This reagent is invaluable for generating intricate peptides tailored for both research and therapeutic purposes.
Protein Engineering: Through the integration of Fmoc-Ala-Ala-Asn(Trt)-OH into protein sequences, scientists can engineer novel proteins with modified properties and functions. The Trt protecting group on the Asn residue enables selective deprotection, facilitating precise alterations to the target protein. This capability is essential for exploring structure-function relationships of proteins and designing innovative biologics.
Bioconjugation: Fmoc-Ala-Ala-Asn(Trt)-OH finds application in crafting peptide conjugates, where peptides are linked to various molecules like drugs or nanoparticles to enhance their efficacy. Particularly in targeted drug delivery systems, the peptide serves as a guiding beacon, directing therapeutic agents to specific cells or tissues. Customization of the peptide sequence elevates the specificity and performance of these conjugates.
Immunology Research: Within immunology, synthetic peptides containing Fmoc-Ala-Ala-Asn(Trt)-OH are harnessed to develop antigenic sequences for vaccine formulations and antibody production. These peptides mimic pathogen epitopes, enabling the investigation of immune responses. Such applications are pivotal in the development of novel vaccines and deepening our understanding of immune mechanisms at the molecular level.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
