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Fmoc-(D-Phe)-OSu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01701 | -- | $-- | Inquiry |
Fmoc-(D-Phe)-OSu, also known as Fluorenylmethoxycarbonyl-D-Phenylalanine-OSu, is a versatile chemical reagent commonly employed in peptide synthesis. Here are four key applications of Fmoc-(D-Phe)-OSu:
Solid-Phase Peptide Synthesis (SPPS): Central to SPPS, Fmoc-(D-Phe)-OSu plays a pivotal role in incorporating D-Phenylalanine residues into peptides. Its affinity for amine groups facilitates efficient coupling, a critical step in crafting peptides with intricate sequences. This methodology lies at the core of peptide generation for diverse research and therapeutic endeavors.
Protease Inhibition Studies: Peptides featuring D-Phenylalanine are instrumental in exploring protease inhibition mechanisms. Fmoc-(D-Phe)-OSu enables the synthesis of these peptides, which act as potent competitive protease inhibitors. Delving into protease interactions aids in formulating novel therapeutic agents for diseases marked by protease aberrations, pushing the boundaries of medical advancement.
Drug Development: Within the pharmaceutical sphere, Fmoc-(D-Phe)-OSu serves as a cornerstone in synthesizing peptide-based drugs. By incorporating D-amino acids like D-Phenylalanine, peptide stability against enzymatic breakdown is bolstered, enhancing the pharmacokinetic attributes of these drugs. This enhancement propels peptide drugs to higher efficacy levels for clinical utility, fostering improved treatment outcomes.
Peptide-Based Diagnostics: In the realm of diagnostics, Fmoc-(D-Phe)-OSu finds application in crafting peptide-based diagnostic tools. Synthetic peptides featuring D-Phenylalanine residues are harnessed in assays and biosensors to detect specific biomolecules. These diagnostic tools play a vital role in early disease detection and monitoring treatment responses, underscoring their significance in healthcare management.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
