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| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00929 | -- | $-- | Inquiry |
For the synthesis of antibody-drug conjugates and other bioconjugates, the versatile Fmoc-D-Val-Cit-PAB linker plays a pivotal role in advancing medical research. Here are four key applications:
Antibody-Drug Conjugates (ADCs) Development: At the forefront of targeted cancer therapies, Fmoc-D-Val-Cit-PAB stands as a cornerstone in the arena of ADCs. This specialized linker plays a crucial role in facilitating the precise release of cytotoxic drugs exclusively within tumor cells, effectively minimizing systemic toxicity.
Peptide Synthesis: Within the intricate realm of peptide synthesis, Fmoc-D-Val-Cit-PAB assumes a critical role as a fundamental building block for constructing complex peptides. Operating as a spacer unit, this linker enables the controlled liberation of desired peptides under specific conditions, ensuring purity and optimizing yield.
Prodrug Design: Harnessing the potential of Fmoc-D-Val-Cit-PAB linkers, prodrug design revolutionizes targeted drug delivery by utilizing specific biological triggers. Incorporating this advanced linker allows prodrugs to remain dormant until encountering designated enzymes or specific pH environments, triggering focused and controlled drug release.
Bioconjugation Techniques: Across diverse bioconjugation methodologies, Fmoc-D-Val-Cit-PAB empowers the attachment of functional molecules to peptides, proteins, and biomolecules, enabling the development of specialized probes for imaging, diagnostics, and therapeutics. This cutting-edge linker elevates the stability and functionality of bioconjugates, opening avenues for enhanced biomedical applications and pioneering research in the field of bioconjugation.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
