MC-PEG2-NH2 - CAS 640267-62-5 Catalog number: BADC-01720

In the realm of drug delivery, MC-PEG2-NH2 (methoxy-capped polyethylene glycol amine) plays a pivotal role due to its unique properties. This bifunctional polyethylene glycol derivative acts as a versatile linker, enabling the conjugation of therapeutic agents, which can significantly enhance their solubility, stability, and bioavailability. These enhancements are crucial for optimizing drug performance, particularly for pharmaceuticals that are poorly soluble or unstable in biological environments. Furthermore, MC-PEG2-NH2 facilitates the creation of long-circulating drug carriers by preventing rapid renal clearance and reducing immunogenicity. This ability to modify pharmacokinetics extends the therapeutic window and effectiveness of various treatments, making it an invaluable tool in the development of new drug delivery systems.

In the field of protein and peptide modification, MC-PEG2-NH2 serves as an essential reagent for enhancing protein stability and solubility. By providing a flexible and hydrophilic spacer, it helps in reducing protein aggregation, which is a common issue leading to loss of biological activity and stability. Moreover, PEGylation, using MC-PEG2-NH2, can improve the half-life of proteins and peptides in the bloodstream, thus increasing their therapeutic efficacy. This modification also mitigates immunogenicity and antigenicity, allowing therapeutic proteins and peptides to maintain their function longer in the body and enabling their use in a wider range of therapeutic applications.

In the context of nanoparticle technology, MC-PEG2-NH2 is instrumental in improving the biocompatibility and functionality of nanoparticles used in various applications. It acts as a surface modifier, ensuring that nanoparticles exhibit reduced opsonization and enhanced circulation time in the body. The polyethylene glycol moiety provides a "stealth" characteristic, helping nanoparticles evade the immune system and accumulate preferentially in target tissues. This property is particularly advantageous in cancer therapy, where targeted delivery of nanoparticles can increase drug concentration at the tumor site while minimizing systemic side effects. MC-PEG2-NH2 thus supports the design of next-generation nanoparticle-based therapeutic and diagnostic agents.

In diagnostic and imaging applications, MC-PEG2-NH2 is utilized to enhance the performance of imaging agents and biosensors. By modifying imaging probes and sensors, it helps in reducing nonspecific interactions with biological matrices, leading to sharper signals and increased specificity. This improvement is vital for accurate diagnostics, allowing for the detection of biomarkers at lower concentrations and facilitating early disease detection. Additionally, the application of MC-PEG2-NH2 in imaging agents improves their pharmacokinetic profiles, resulting in better tissue penetration and retention, thus providing more detailed and informative imaging results. Overall, the use of MC-PEG2-NH2 in these areas contributes to the advancement of various diagnostic and imaging modalities, expanding their clinical and research applications.