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m-PEG6-NHS ester is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-00954 | -- | $-- | Inquiry |
mPEG6-NHS ester, a versatile reagent in bioconjugation and surface modification, is utilized across protein chemistry and biotechnology for a myriad of applications.
Protein and Peptide Modification: Positioned as a cornerstone in protein engineering, mPEG6-NHS ester emerges as a pivotal player for augmenting the solubility, stability, and biocompatibility of proteins and peptides. Through strategic conjugation with amino groups on lysine residues, researchers cloak proteins to shield them from immunogenic responses.
Surface Coating: In the realm of advancing biomaterials, mPEG6-NHS ester assumes a critical role in surface engineering, particularly in the coating of medical devices and implants to mitigate protein adsorption and cell adhesion. This innovative PEGylation strategy erects a hydrophilic barricade to curb fouling and enhance surface biocompatibility, thereby prolonging the functionality and longevity of implanted biomedical equipment.
Drug Delivery: Embarking on the journey towards optimized drug delivery systems, mPEG6-NHS ester shines as a linchpin in the modification of nanoparticles and liposomes. By skillfully PEGylating the carrier surface, scientists prolong circulation time in the bloodstream, elevating drug stability and bioavailability.
Diagnostic Applications: Within diagnostic realms, mPEG6-NHS ester assumes a pivotal role in amplifying the precision and reliability of assays by conjugating PEG chains to antibodies and detection molecules. This strategic modification diminishes nonspecific binding, amplifying sensitivity and accuracy in assays such as ELISAs.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
