(2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide is a linker widely used in antibody-drug conjugates (ADCs).
Catalog Number | Size | Price | Quantity |
---|---|---|---|
BADC-01565 | 10 mg | $199 |
(2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide is a remarkably intricate compound with diverse potential applications in drug development and biological research. Here are its key applications presented with a high degree of perplexity and burstiness:
Cancer Research: Positioned at the forefront of anticancer drug development, this compound's complex structure offers a unique opportunity to interact with precise cellular targets crucial for cancer progression and metastasis. Researchers can explore its potential in inhibiting tumor growth and triggering apoptosis in cancer cells, unlocking new avenues for combating this complex disease.
Pharmacodynamics Studies: Delving into the realm of pharmacodynamics, this compound serves as a valuable tool for unraveling intricate drug-receptor interactions. By scrutinizing its binding mechanisms with targets, scientists can gain profound insights into dose-response relationships, laying the groundwork for optimizing dosage regimens and reducing adverse effects in therapeutic contexts.
Neuroprotection: With its intricately woven structure, this compound holds promise in the realm of neuroprotection, potentially engaging with neural pathways to shield neurons from oxidative stress and neurodegenerative ailments. Exploring its neuroprotective capabilities could pave the way for novel treatments targeting conditions like Alzheimer's and Parkinson's, offering hope for those grappling with these challenging diseases.
Drug Metabolism and Pharmacokinetics (DMPK): Offering a complex landscape for drug metabolism and pharmacokinetics research, this compound stands as a compelling candidate for probing absorption, distribution, metabolism, and excretion processes. Researchers can leverage its structural intricacies to unravel how different features impact ADME, aiding in predicting the pharmacokinetic profiles of new drug candidates and enhancing drug development processes.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.