(S,E)-TCO2-PEG4-NHS ester

(S,E)-TCO2-PEG4-NHS ester Catalog number: BADC-01905

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(S,E)-TCO2-PEG4-NHS ester is an ADC linker containing 4 PEG units.

Category
ADCs Linker
Product Name
(S,E)-TCO2-PEG4-NHS ester
Catalog Number
BADC-01905
Molecular Formula
C24H38N2O10
Molecular Weight
514.57

Ordering Information

Catalog Number Size Price Quantity
BADC-01905 -- $--
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Description
(S,E)-TCO2-PEG4-NHS ester is an ADC linker containing 4 PEG units.
IUPAC Name
(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[[(1S,2E)-cyclooct-2-en-1-yl]oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES
C1CCC=CC(CC1)OC(=O)NCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O
InChI
InChI=1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h4,6,20H,1-3,5,7-19H2,(H,25,30)/b6-4+/t20-/m1/s1
InChIKey
VIRDRNWTHXGGOW-PEAOBZDDSA-N

(S,E)-TCO2-PEG4-NHS ester, a versatile chemical linker utilized in diverse bioscience applications, plays a pivotal role in various key applications characterized by high perplexity and burstiness.

Bioconjugation: (S,E)-TCO2-PEG4-NHS ester serves as a fundamental tool in bioconjugation, facilitating the linkage of biomolecules like proteins, peptides, and antibodies through the formation of stable amide bonds with primary amines. This intricate process enables targeted delivery and enhanced solubility of therapeutic molecules, essential for advancing antibody-drug conjugates and diagnostic assays towards groundbreaking discoveries.

Drug Delivery: The incorporation of the hydrophilic PEG segment in (S,E)-TCO2-PEG4-NHS ester elevates the solubility and biocompatibility of drug molecules, making it a preferred choice for modifying drug carriers such as liposomes and nanoparticles. This enhancement optimizes circulation time and diminishes immunogenicity, resulting in more effective and precise drug delivery mechanisms with profound implications for medical advancements.

Surface Modification: Leveraging (S,E)-TCO2-PEG4-NHS ester for surface modification of medical devices and biosensors introduces antifouling properties and diminishes non-specific binding, crucial for enhancing device performance and durability. By creating a hydrophilic barrier through PEG chain attachment, the linker resists protein adsorption and cell adhesion, thus revolutionizing the landscape of implants and diagnostic devices with a focus on longevity and efficacy.

Proteomics and Protein Labeling: In the realm of proteomic studies, (S,E)-TCO2-PEG4-NHS ester emerges as a pivotal component for protein labeling, enabling researchers to identify and quantify proteins with precision. Through covalent attachment of fluorescent dyes or affinity tags, scientists gain insights into protein interactions, post-translational modifications, and expression levels, thereby unlocking high-throughput screening capabilities and deepening the comprehension of intricate biological systems.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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