1-N-Boc-3-hydroxyazetidine - CAS 141699-55-0

1-N-Boc-3-hydroxyazetidine - CAS 141699-55-0 Catalog number: BADC-01651

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1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker and also an alkyl chain-based PROTAC linker.

Category
ADCs Linker
Product Name
1-N-Boc-3-hydroxyazetidine
CAS
141699-55-0
Catalog Number
BADC-01651
Molecular Formula
C8H15NO3
Molecular Weight
173.21
1-N-Boc-3-hydroxyazetidine

Ordering Information

Catalog Number Size Price Quantity
BADC-01651 -- $--
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Description
1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker and also an alkyl chain-based PROTAC linker.
Synonyms
1-Boc-3-hydroxyazetidine; N-Boc-3-hydroxyazetidine; 1-(tert-Butoxycarbonyl)-3-hydroxyazetidine; 3-Hydroxy-azetidine-1-carboxylic acid tert-butyl ester
IUPAC Name
tert-butyl 3-hydroxyazetidine-1-carboxylate
Canonical SMILES
CC(C)(C)OC(=O)N1CC(C1)O
InChI
InChI=1S/C8H15NO3/c1-8(2,3)12-7(11)9-4-6(10)5-9/h6,10H,4-5H2,1-3H3
InChIKey
XRRXRQJQQKMFBC-UHFFFAOYSA-N
Density
1.184±0.06 g/cm3
Melting Point
36-43°C
LogP
0.53590
Storage
Keep in dark place, Sealed in dry, Room Temperature
Signal Word
Danger
Boiling Point
253.7±33.0 °C at 760 mmHg

1-N-Boc-3-hydroxyazetidine, a pivotal compound in organic synthesis, boasts diverse applications in scientific research and industry. Here are four key applications presented with high perplexity and burstiness:

Pharmaceutical Synthesis: Serving as a crucial intermediate, 1-N-Boc-3-hydroxyazetidine plays a prominent role in pharmaceutical compound synthesis. Its distinctive structure, featuring both a Boc-protected amine and a hydroxy group, enables the intricate construction of complex molecules. This inherent versatility is instrumental in the creation of novel drugs and the optimization of synthetic pathways, propelling innovation in the realm of pharmaceuticals.

Peptide Synthesis: Within the domain of peptide synthesis, 1-N-Boc-3-hydroxyazetidine acts as a foundational building block for the production of innovative amino acid derivatives. Integrating this compound into peptide sequences can result in the generation of peptides endowed with heightened stability and enhanced biological activity. This application is essential for the synthesis of peptides with therapeutic relevance, driving advancements in the field of peptide-based therapeutics.

Material Science: The utilization of 1-N-Boc-3-hydroxyazetidine in material science is particularly noteworthy, contributing to the development of cutting-edge polymers and materials. Its capacity to form stable, functionalized structures renders it ideal for crafting advanced materials tailored to specific properties. This capability finds application in diverse fields such as drug delivery systems and the creation of environmentally friendly, biodegradable plastics, showcasing the versatility of this compound in material design.

Medicinal Chemistry: In the realm of medicinal chemistry, 1-N-Boc-3-hydroxyazetidine serves as a pivotal tool for exploring structure-activity relationships (SAR) in drug discovery endeavors. By judiciously modifying this compound, researchers can curate a diverse library of analogs to pinpoint potent and selective drug candidates. This strategic approach expedites the discovery and development of novel therapeutic agents, driving forward innovation in the domain of medicinal chemistry.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: 1-N-Boc-3-hydroxyazetidine
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