Catalog Number | Size | Price | Quantity |
---|---|---|---|
BADC-01967 | -- | $-- |
Fmoc-(2R4R)-4-azidoproline, a versatile chemical compound, finds extensive utility in peptide synthesis and bioconjugation. Here are four key applications of Fmoc-(2R4R)-4-azidoproline:
Peptide Synthesis: Integral to synthetic peptides, Fmoc-(2R4R)-4-azidoproline boasts a distinct azide functional group, facilitating site-specific modifications through click chemistry. Researchers utilize this compound to craft modified peptides with augmented stability or bioactivity, crucial for advancements in drug development and protein engineering.
Bioconjugation: Harnessing the reactive azide group in Fmoc-(2R4R)-4-azidoproline, researchers engage in the highly efficient Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction with alkyne-containing molecules. This process enables precise conjugation of diverse biomolecules like fluorophores, drugs, or imaging agents to peptides or proteins, fostering the development of targeted therapeutics and diagnostic tools.
Structural Biology: By incorporating Fmoc-(2R4R)-4-azidoproline into proteins, researchers gain the ability to introduce controlled structural modifications. Through selective protein modification or cross-linking, scientists delve into protein folding, stability, and interactions with other biomolecules, offering insights into protein structure-function relationships and facilitating the design of stable protein constructs for therapeutic purposes.
Chemical Biology: In the realm of chemical biology, Fmoc-(2R4R)-4-azidoproline serves as a pivotal component in designing chemical probes for investigating biological systems. Chemical probes containing this azide proline can label, track, or inhibit specific biomolecules within cellular environments, aiding in the mapping of cellular pathways, identification of interaction networks, and discovery of potential drug targets.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.