2,5-Dioxopyrrolidin-1-yl 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate is a linker widely used in antibody-drug conjugates (ADCs).
Catalog Number | Size | Price | Quantity |
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BADC-01546 | -- | $-- |
2,5-Dioxopyrrolidin-1-yl 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate is extensively used in the field of bioconjugation techniques. This compound acts as an effective crosslinker that facilitates the linkage of biomolecules such as peptides, proteins, and nucleic acids. The ester component in its structure reacts with primary amines present in these biomolecules, forming stable amide bonds. This characteristic is crucial for creating conjugates that are utilized in diagnostic assays, targeted drug delivery systems, and molecular imaging. The robustness and specificity of the conjugation reaction make it a valuable tool in the development of advanced biotechnological applications.
Another significant application of 2,5-Dioxopyrrolidin-1-yl 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate is in the synthesis of pharmaceutical intermediates. This compound serves as a key starting material in the synthesis of various bioactive molecules, particularly those used in anti-inflammatory and anticancer therapies. Its ability to form highly reactive intermediates allows for the introduction of specific functional groups necessary for the pharmacological activity of the final drug molecules. By leveraging this compound in synthetic pathways, pharmaceutical chemists can enhance the efficiency and yield of the drug development process, thereby accelerating the production of new therapeutic agents.
The compound is also employed in surface modification techniques, particularly for enhancing the biocompatibility and functionality of biomedical implants and devices. By grafting 2,5-Dioxopyrrolidin-1-yl 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate onto the surfaces of materials such as metals, polymers, and ceramics, researchers can introduce functional groups that improve cell adhesion, protein binding, and antimicrobial properties. This surface modification is essential for the development of advanced medical devices like stents, catheters, and biosensors, ensuring they perform effectively in clinical settings and promote patient healing and recovery.
In the realm of polymer chemistry, 2,5-Dioxopyrrolidin-1-yl 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate is utilized as a monomer for creating specialized functional polymers. These polymers exhibit unique properties, such as enhanced mechanical strength, thermal stability, and chemical resistance, which are advantageous for various industrial applications. For instance, functional polymers synthesized from this compound are used in the production of high-performance coatings, adhesives, and resins. Additionally, these polymers are explored in the development of smart materials with responsive behaviors to environmental stimuli, opening up new possibilities in material science and engineering.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.