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Amino-bis-PEG3-DBCO is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01207 | -- | $-- |
Amino-bis-PEG3-DBCO, a multifaceted bifunctional reagent widely utilized in bioconjugation and molecular biology, boasts a myriad of applications. Here are four key applications characterized by heightened perplexity and burstiness:
Protein Labeling: The utilization of Amino-bis-PEG3-DBCO for precise protein labeling involves the intricate strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. This reagent facilitates selective conjugation to azide-containing biomolecules without the need for copper catalysts, which can be detrimental to biological systems. The resulting stable and biocompatible linkage is conducive to imaging and diagnostic pursuits, showcasing a sophisticated approach to bioconjugation.
Drug Delivery Systems: Positioned at the forefront of targeted drug delivery systems, Amino-bis-PEG3-DBCO serves as a crucial element for tethering therapeutic agents to targeting moieties. This union enables the creation of multifunctional nanoparticles capable of delivering drugs directly to specific cells or tissues. Such precision in drug delivery not only amplifies therapeutic efficacy but also mitigates unwanted side effects, heralding a new age of precision medicine marked by intricate bioconjugation strategies.
Bioconjugation for Diagnostic Assays: A pivotal player in crafting bioconjugates essential for diagnostic assays, Amino-bis-PEG3-DBCO plays a vital role in biomolecule detection realms. By attaching fluorescent or enzymatic probes to antibodies or other binding partners, researchers can fabricate highly sensitive and specific assays crucial for medical diagnostics, environmental surveillance, and investigative research. This intricate bioconjugation technique elevates the precision and reliability of diagnostic assays through its strategic application in the field.
Surface Functionalization: The versatility of Amino-bis-PEG3-DBCO extends to surface modification with bioactive molecules, catering to a wide array of applications ranging from biosensors to bioengineered scaffolds. Leveraging the flexibility of the PEG linker, this technique minimizes nonspecific interactions, thereby enhancing the stability and functionality of immobilized molecules. Such adept surface functionalization techniques are indispensable for propelling the development of state-of-the-art biosensors and cutting-edge tissue engineering materials, underscoring the intricate nature of bioconjugation in surface modification.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
