APN-PEG4-BCN

APN-PEG4-BCN Catalog number: BADC-01217

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Category
ADCs Linker
Product Name
APN-PEG4-BCN
Catalog Number
BADC-01217
Molecular Formula
C31H39N3O7
Molecular Weight
565.66

Ordering Information

Catalog Number Size Price Quantity
BADC-01217 -- $--
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Solubility
10 mm in DMSO
Purity
≥95%
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
Room temperature, or blue ice upon request.
Storage
-20°C

APN-PEG4-BCN, a versatile bifunctional linker utilized in the realms of chemical biology and bioconjugation, finds wide-ranging applications across various domains. Here are four key applications of APN-PEG4-BCN:

Protein Labeling: A common practice in research, the utilization of APN-PEG4-BCN in protein labeling serves as a pivotal tool for attaching tags or probes to specific proteins. The BCN (bicyclo[6.1.0]nonyne) moiety partakes in a copper-free click reaction with azide-functionalized molecules, ensuring precise and enduring attachment. This methodology empowers researchers to monitor proteins within intricate cellular environments and investigate protein-protein interactions with meticulous detail.

Drug Delivery: Embarking on a journey toward advanced drug delivery systems, the conjugation of therapeutic agents to biocompatible carriers using APN-PEG4-BCN opens new horizons. The inclusion of the PEG (polyethylene glycol) component augments solubility and diminishes immunogenicity, thereby elevating drug efficacy and stability. By linking drugs to specifically tailored carriers, targeted delivery to precise tissues or cells is achieved, leading to a substantial reduction in undesirable side effects while maximizing therapeutic impact.

Diagnostic Imaging: In the realm of diagnostic imaging, APN-PEG4-BCN emerges as a valuable asset in the creation of imaging agents crucial for visualizing biological processes in vivo. By coupling imaging probes like fluorescent dyes or radioisotopes to peptides or antibodies, this compound plays a pivotal role in disease diagnosis, monitoring therapeutic responses, and guiding intricate surgical procedures. Its contribution to enhancing imaging precision and efficacy is instrumental in the evolution of medical diagnostics.

Biomaterials Development: The application of APN-PEG4-BCN in biomaterials modification signifies a significant stride toward enhancing material functionality. By tethering this compound to surfaces of medical implants or scaffolds, biocompatibility and cellular adhesion are promoted, rendering the materials more suitable for applications in tissue engineering and regenerative medicine. This transformative approach holds the potential to revolutionize the field of biomaterials, creating opportunities for innovative solutions in healthcare and beyond.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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