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Biotin-PEG3-aldehyde is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01232 | -- | $-- | Inquiry |
Biotin-PEG3-aldehyde, a versatile molecule with a myriad of applications in biochemistry and biomedicine, stands as a fundamental constituent in various contexts. Below are four key applications showcased with a high degree of perplexity and burstiness:
Protein Labeling: Delving into the realm of protein labeling, Biotin-PEG3-aldehyde emerges as a pivotal agent facilitating the formation of covalent bonds with proteins and peptides via targeted interactions with primary amines. This biotinylation process enables precise and specific labeling, leading to applications in affinity purification and a plethora of detection assays driven by the robust binding affinity between biotin and streptavidin.
Surface Modification: Expanding its influence to surface modification, this compound plays a critical role in the biotinylation of diverse surfaces, unlocking possibilities in bioassays and biosensors. By integrating Biotin-PEG3-aldehyde into surfaces such as beads, slides, or microplate wells, researchers establish biotin-functionalized interfaces conducive to the immobilization of streptavidin-conjugated molecules. This enhancement bolsters the specificity and sensitivity of detection systems, propelling advancements in biosensing technologies to new heights.
Cell Biology: Venturing into the intricate landscape of cell biology, Biotin-PEG3-aldehyde emerges as a transformative asset for modifying cell surface proteins, fueling applications in cell targeting and tracking. By biotinylating cells and subsequently capturing or labeling them with streptavidin-conjugated tools, researchers unlock the potential to explore cell-cell interactions, receptor-ligand binding, and various cellular processes with precision and control.
Drug Delivery: In the dynamic realm of drug delivery research, the utility of Biotin-PEG3-aldehyde shines through in the functionalization of drug carriers like nanoparticles or liposomes with biotin tags. This innovative biotinylation approach forms the foundation for targeted drug delivery to specific tissues or cells by leveraging the biotin-streptavidin interaction, thereby enhancing therapeutic efficacy while minimizing off-target effects. This targeted strategy elevates treatment outcomes, underscoring the indispensable role of Biotin-PEG3-aldehyde in propelling advancements in drug delivery paradigms.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
