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Boc-L-4-trans-hydroxyproline methyl ester is a non-cleavable ADC linker and also an alkyl chain-based PROTAC linker.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01927 | -- | $-- |
Boc-L-4-trans-hydroxyproline methyl ester, a protected derivative of 4-trans-hydroxyproline, plays a pivotal role in bioscience and chemical research. Here are four key applications:
Peptide Synthesis: Widely employed in peptide and protein synthesis, Boc-L-4-trans-hydroxyproline methyl ester is instrumental in exploring the function of hydroxyproline in collagen stability and activity. Researchers utilize this ester to construct peptides that replicate natural proteins, facilitating in-depth structural and functional assessments.
Drug Development: In the realm of medicinal chemistry, this compound holds significant value for crafting proline-rich peptides and small molecules with potential therapeutic applications. These peptides serve as promising drug candidates for conditions like fibrosis and cancer. The utilization of Boc-protected hydroxyproline allows for meticulous refinement and enhancement of drug characteristics.
Structural Biology: Within structural biology, Boc-L-4-trans-hydroxyproline methyl ester is a critical tool for probing protein folding and stability. The presence of hydroxyproline residues influences the three-dimensional structures of proteins, such as collagen. Incorporating this ester into protein constructs enables scientists to analyze its impact on protein structure and stability using advanced techniques like X-ray crystallography and NMR spectroscopy.
Biotechnology: In the field of biotechnology, Boc-L-4-trans-hydroxyproline methyl ester is harnessed to engineer modified enzymes and proteins with superior properties. By integrating hydroxyproline into protein sequences, researchers can enhance thermal stability, proteolysis resistance, and overall protein functionality. This capability proves invaluable in industrial settings where robust and enduring proteins are essential for various applications.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
