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Cys-MC-VC-PAB-MMAE is an ADC metabolite used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01434 | -- | $-- | Inquiry |
Cys-MC-VC-PAB-MMAE, a complex molecule integral to targeted cancer therapy through antibody-drug conjugates (ADCs), showcases a myriad of applications. Here are four key applications:
Targeted Cancer Therapy: The strategic use of Cys-MC-VC-PAB-MMAE in ADCs facilitates the precise delivery of the potent cytotoxin MMAE directly to malignant cells. The conjugate’s selective binding to cancer cell antigens enables internalization and controlled release of MMAE within tumor cells. This targeted approach minimizes off-target effects, elevating treatment effectiveness and presenting a promising strategy for battling diverse forms of cancer.
Clinical Oncology Research: Critical for preclinical and clinical investigations, Cys-MC-VC-PAB-MMAE serves as a pivotal tool in assessing the efficacy and safety of novel ADCs. By scrutinizing the pharmacokinetics and pharmacodynamics of these conjugates, scientists can fine-tune dosing schedules and therapeutic windows. This research is fundamental in propelling innovative cancer therapies from experimental phases to practical implementation in clinical environments.
Cell Line Development: Within the realms of biotechnology and pharmaceutical exploration, Cys-MC-VC-PAB-MMAE plays a crucial role in constructing and evaluating engineered cell lines. These engineered cells express specific antigens or receptors, aiding in the evaluation of binding affinity and effectiveness of antibody-drug conjugates. This process assists in the exploration and validation of new therapeutic targets in cancer treatment.
Drug Resistance Studies: Serving as a cornerstone in unraveling drug resistance mechanisms in cancer cells, Cys-MC-VC-PAB-MMAE offers invaluable insights. By subjecting resistant cell lines to this conjugate, researchers can analyze alterations in gene expression, protein levels, and signaling pathways. These revelations are vital for formulating strategies to combat resistance and enhance treatment outcomes in the ongoing battle against cancer.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
