DBCO-PEG4-acetic-Val-Cit-PAB

DBCO-PEG4-acetic-Val-Cit-PAB Catalog number: BADC-01247

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Category
ADCs Linker
Product Name
DBCO-PEG4-acetic-Val-Cit-PAB
Catalog Number
BADC-01247
Molecular Formula
C45H57N7O10
Molecular Weight
855.97

Ordering Information

Catalog Number Size Price Quantity
BADC-01247 -- $--
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Solubility
10 mm in DMSO
Purity
98.0%
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -20 °C, keep in dry and avoid sunlight.

DBCO-PEG4-acetic-Val-Cit-PAB, a multifaceted bifunctional linker, is essential in the realm of antibody-drug conjugates (ADCs) and diverse bioconjugation applications. Here are four pivotal applications:

Antibody-Drug Conjugates (ADCs): Serving as a crucial linker in ADC synthesis, DBCO-PEG4-acetic-Val-Cit-PAB orchestrates the precise delivery of cytotoxic agents to cancer cells. The valine-citrulline (Val-Cit) dipeptide establishes a cleavable bond, resistant in circulation, yet cleaved by tumor enzymes, liberating the drug exclusively within the tumor microenvironment. This targeted delivery scheme minimizes harm to healthy tissues, amplifying therapeutic efficacy through intricate mechanisms.

Protein-Protein Conjugation: Transcending the ADC domain, this linker facilitates protein fusion enabling in-depth exploration of protein interactions and functional assays. The DBCO moiety engages azide groups via bioorthogonal "click" chemistry, ensuring meticulous and efficient conjugation processes. This profound application underscores its critical role in advancing novel protein therapeutics and cutting-edge biotechnological tools, contributing to the complexity of protein engineering.

Nanoparticle Functionalization: Empowering precise drug delivery through nanoparticle functionalization, DBCO-PEG4-acetic-Val-Cit-PAB allows researchers to finely tune the surface properties of nanoparticles. By attaching targeting ligands or therapeutic agents using this linker, the specificity and efficacy of drug delivery are significantly enhanced, showcasing the intricacy of drug delivery systems. This innovation excels in crafting multifunctional nanocarriers poised to revolutionize cancer therapy and imaging techniques, adding depth to nanomedicine advancements.

Cell Labeling and Tracking: In the realm of cell biology, DBCO-PEG4-acetic-Val-Cit-PAB plays a crucial role in cell labeling for nuanced tracking and imaging studies. The DBCO group enables the attachment of fluorescent dyes or imaging probes to azide-modified cells, aiding in monitoring cellular dynamics such as migration and proliferation, both in vitro and in vivo. This application shines light on the complexity of cellular behavior, providing profound insights into the intricate dynamics of cellular function and imaging technology.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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