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DBCO-Peg4-VC-PAB-MMAE is a cytotoxin and linker conjugate widely used in ADCs.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01536 | -- | $-- | Inquiry |
DBCO-Peg4-VC-PAB-MMAE, a sophisticated molecule utilized primarily in targeted cancer therapy, boasts a myriad of crucial applications. Here are four key applications:
Antibody-Drug Conjugates (ADCs): At the forefront of cancer therapeutics, DBCO-Peg4-VC-PAB-MMAE plays a pivotal role in the development of ADCs, acting as a potent cytotoxic payload. These ADCs are designed with antibodies that specifically target cancer cells, ensuring precise delivery of the cytotoxic agent to the tumor site. This targeted precision minimizes harm to healthy cells and elevates the therapeutic efficacy of cancer treatments.
Tumor Ablation: Employed in the eradication of cancerous tissues, DBCO-Peg4-VC-PAB-MMAE induces apoptosis in malignant cells. Once infiltrating tumor cells, the MMAE component disrupts microtubule networks, causing cell cycle arrest and eventual cell death. This mechanism proves particularly efficacious in addressing various lymphomas and solid tumors, offering a potent treatment strategy.
Bioconjugation Studies: Leveraging the DBCO moiety within DBCO-Peg4-VC-PAB-MMAE, researchers conduct bioconjugation reactions to link the molecule with peptides or proteins. This click chemistry methodology facilitates precise and stable conjugation of molecules, enhancing the development of advanced therapeutic and diagnostic agents. The incorporation of the PEG4 spacer bolsters the solubility and stability of the conjugates, thereby amplifying their biological functionality.
Preclinical Cancer Research: Vital for validating the efficacy and safety of novel cancer treatments, DBCO-Peg4-VC-PAB-MMAE shines in preclinical cancer research. Researchers delve into its pharmacokinetics, biodistribution, and therapeutic potential in animal models, laying the groundwork for optimizing ADC formulations and propelling them towards clinical trials, marking a significant stride in cancer research and treatment innovation.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
