DBCO-SS-PEG4-Biotin

DBCO-SS-PEG4-Biotin Catalog number: BADC-01254

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category
ADCs Linker
Product Name
DBCO-SS-PEG4-Biotin
Catalog Number
BADC-01254
Molecular Formula
C45H62N6O9S3
Molecular Weight
927.20

Ordering Information

Catalog Number Size Price Quantity
BADC-01254 -- $--
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Canonical SMILES
C1C2C(C(S1)CCCCCC(=O)NCCOCCOCCOCCOCCC(=O)NCCSSCCNC(=O)CCC(=O)N3CC4=CC=CC=C4C#CC5=CC=CC=C53)NC(=O)N2
InChI
InChI=1S/C45H62N6O9S3/c52-40(13-3-1-2-12-39-44-37(33-61-39)49-45(56)50-44)46-19-23-58-25-27-60-29-28-59-26-24-57-22-18-42(54)48-21-31-63-62-30-20-47-41(53)16-17-43(55)51-32-36-10-5-4-8-34(36)14-15-35-9-6-7-11-38(35)51/h4-11,37,39,44H,1-3,12-13,16-33H2,(H,46,52)(H,47,53)(H,48,54)(H2,49,50,56)/t37-,39-,44-/m0/s1
InChIKey
ZUNYXNOVQARZNV-LJFGWUDESA-N
Solubility
10 mm in DMSO
Appearance
Light yellow oil
Purity
≥95%
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
Room temperature
Storage
Store at -20 °C, keep in dry and avoid sunlight.

DBCO-SS-PEG4-Biotin is a multifunctional reagent used in bioconjugation techniques. Here are some key applications of DBCO-SS-PEG4-Biotin:

Bioconjugation: DBCO-SS-PEG4-Biotin is frequently used to label biomolecules with biotin, facilitating their subsequent capture or detection using streptavidin-based systems. Its DBCO group allows for selective and efficient conjugation with azide-modified molecules through copper-free Click Chemistry. This makes it ideal for bioorthogonal labeling in live cells or complex biological samples.

Protein Purification: The biotin moiety on DBCO-SS-PEG4-Biotin enables affinity-based purification of proteins. By tagging proteins with this reagent, they can be easily isolated using streptavidin-coated beads or columns. This method is highly effective for purifying proteins without affecting their activity or function, which is critical for downstream applications.

Drug Delivery: DBCO-SS-PEG4-Biotin can be used in the development of targeted drug delivery systems. By biotinylating drug carriers or therapeutic agents, specific targeting can be achieved through biotin-streptavidin interactions. This approach enhances the precision of drug delivery, reducing side effects and increasing efficacy.

Diagnostic Assays: In diagnostic applications, DBCO-SS-PEG4-Biotin is employed to create biotinylated probes and capture molecules. These biotin-tagged entities can bind to streptavidin-coated surfaces, facilitating the detection of target analytes in assays such as ELISA and Western blotting. The use of this reagent thus enhances sensitivity and specificity in diagnostic testing.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: DBCO-SS-PEG4-Biotin
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